Parameswaran et al., J Biol Chem 2006
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Upon LPS stimulation, IkappaB kinase promotes phosphorylation and degradation of NFkappaB1 p105 ( p105 ) , which releases TPL2 ( a MAP3K ), which phosphorylates MEK1/2, which in turn phosphorylates ERK1/2
Naumann et al., EMBO J 1994
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As an in vitro model we show that phosphorylation of p105 impedes its ability to interact with NF-kappa B , as has been shown before for I kappa B alpha
Fujimoto et al., Gene 1995
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p105 also functions as a cytoplasmic inhibitor for NF-kappa B, and the proteolytic processing of its inhibitory C-terminal region is required for generation of active NF-kappa B