Gene interactions and pathways from curated databases and text-mining

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GRAP2 — IL12A

Text-mined interactions from Literome

Feng et al., J Immunol 1999 : Extracellular signal related kinase ( ERK ) and p38 mitogen activated protein ( MAP ) kinases differentially regulate the lipopolysaccharide mediated induction of inducible nitric oxide synthase and IL-12 in macrophages : Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
NĂ©meth et al., Biochim Biophys Acta 2001 : Furthermore, the inhibitory effect of amiloride on IL-12 p40 production was not a result of interference with the activation of the p38 and p42/44 mitogen activated protein kinases or c-Jun kinase
Kang et al., Biochem Pharmacol 2002 : Berberine induced IL-12 p40 production and activation of p38 mitogen activated protein kinase ( MAPK ) in dose dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha ( 2 ) -adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine
Dai et al., J Immunol 2005 : Gal-9 induced phosphorylation of the MAPK p38 and ERK1/2 in DCs, and an inhibitor of p38 signaling, but not inhibitors of signaling by either ERK1/2 or PI3K, blocked Gal-9 induced up-regulation of costimulatory molecule expression and IL-12 production
Koch et al., Respir Med 2007 (Asthma) : The modulatory role of extracellular signal regulated kinase ( ERK ) -1/-2, p38mitogen activated protein kinase ( MAPK ) and dexamethasone on IL-12 induced T-bet and IFNgamma expression was assessed in peripheral blood lymphocytes of 10 atopic asthmatics and 10 nonatopic normals
Sodhi et al., Glycoconj J 2007 : Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C, p42/44, p38 , JNK and intracellular calcium immobilizing agent down regulated the WGA induced expression of cytokines TNF-alpha, IL-1beta, IL-12 and IFN-gamma
Kang et al., Cytokine 2009 : Induction of IL-12 by LMM in peritoneal macrophages involved NF-kappaB, p38 and JNK, but not ERK1/2