Gene interactions and pathways from curated databases and text-mining

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IL10 — IL22

Text-mined interactions from Literome

Qiu et al., Zhongguo Yao Li Xue Bao 1999 : Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages
Kelly et al., Reproduction 2001 : Prostaglandins have major effects on cytokine production but the direct action of prostaglandin E on leucocytes is not a pro-inflammatory response but is to stimulate interleukin 10 and inhibit interleukin 12 synthesis
Byrnes et al., Ann Neurol 2002 (Multiple Sclerosis, Chronic Progressive...) : Interleukin-10 , a dominant endogenous inhibitor of interleukin-12 , is largely protective in these experimental surrogates for multiple sclerosis
Puliti et al., Arthritis Rheum 2002 (Arthritis, Infectious...) : The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production
Uchimura et al., Clin Exp Immunol 2002 (Graves Disease) : The effects of CD40- and interleukin ( IL-4 ) -activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves ' disease : the role of CD8+ cells
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Chiang et al., Am J Respir Crit Care Med 2003 (Asthma...) : The data showed that ribavirin and ODN 1826 increased interleukin-12 synthesis and inhibited interleukin-10 production
Jani et al., Plant Cell Rep 2004 : Macrophages isolated from mice immunised with native or plant expressed CTB showed enhanced secretion of interleukin-10 but secretion of lipopolysaccharide induced interleukin-12 and tumor necrosis factor alpha was inhibited
Weir et al., Infect Immun 2004 (Tuberculosis) : Mycobacterial purified protein derivatives stimulate innate immunity : Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom ... To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives ( PPDs )
Zhou et al., Mol Cell Biol 2004 : Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway
Nagalakshmi et al., Int Immunopharmacol 2004 : Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells ... Induction of IL-10 by IL-22 , in Colo205 cells, could be inhibited in the presence of a neutralizing antibody against IL-10R2
Romano et al., Clin Immunol 2005 (Acute Disease...) : The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects
Obonyo et al., FEMS Immunol Med Microbiol 2006 (Helicobacter Infections) : Evidence for interleukin-1 independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori infected murine dendritic cells deficient in the interleukin-1 receptor
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Yin et al., J Toxicol Environ Health 2007 (Listeriosis) : DEP or eDEP concentration-dependently suppressed L. monocytogenes induced secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-12 by AM and of IL-2 and interferon-gamma by lymphocytes obtained from L. monocytogenes infected rats, but augmented the AM secretion of IL-10
Buisson et al., J Infect Dis 2009 (HIV Infections) : These functional changes may be at least partly explained by reduced interleukin-12 and increased interleukin-10 secretion on stimulation with lipopolysaccharide and CD40 ligand
Li et al., Immunol Cell Biol 2010 (Hepatitis B, Chronic) : Furthermore, endogenous IL-10 inhibited HBcAg stimulated production of IL-17A, IL-22 , IL-6 and IL-23, but not TGF-ß
Marijnissen et al., Arthritis Rheum 2011 (Arthritis, Experimental...) : Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation
Wang et al., PloS one 2011 (Liposarcoma) : IL-22 overexpression promotes production of inflammatory cytokines such as IL-1ß and IL-10 and stimulates ERK phosphorylation in adipose tissue ... Furthermore, IL-22 treatment in differentiated 3T3-L1 adipocytes could induce IL-1ß and IL-10 expression, together with stimulation of ERK phosphorylation
Ding et al., ACS Appl Mater Interfaces 2011 : The inhibition of inducible nitric oxide synthase and interleukin-1 expression and the activation of interleukin-10 were increased with increasing gelatin content
Uchiyama et al., Journal of cardiothoracic surgery 2012 : Proliferation of splenocytes, interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of IL-4 and IL-10 from opera exposed transplant recipients increased compared to that from splenocytes of untreated recipients
Chung et al., J Infect Dis 2013 (Leprosy, Lepromatous...) : Galectin-3 enhanced monocyte interleukin 10 production to a TLR2/1 ligand, whereas interleukin 12p40 secretion was unaffected
Sarkar et al., Arthritis Rheum 2013 (Arthritis, Experimental...) : IL-22 augmented IL-10 , IL-17, and IL-6 in lymphoid tissues in vitro
Wang et al., Immunol Lett 2013 : In addition, the suppression of IL-22 is not dependent on the production of IFN-? and IL-10
Thompson et al., J Neurotrauma 2013 (Spinal Cord Injuries) : The best characterized effects of IL-10 are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß), interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-a, interferon-?, matrix metalloproteinase-9, nitric oxide synthase, myeloperoxidase, and reactive oxygen species
Tilg et al., Cytokine 1995 (Neoplasms) : Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy
Benveniste et al., Proc Natl Acad Sci U S A 1996 (Acute Disease...) : Comparative interleukin ( IL-2 ) /interferon IFN-gamma and IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Venkataraman et al., Cryobiology 1996 : X. Decrease in interleukin-12 production by frozen human peripheral blood mononuclear cells is mediated by the endogenously hypersecreted interleukin-10
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10 , transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Pai et al., Oncol Res 1998 : Differential effect of interleukin 10 on interleukin 12- and interleukin 2-mediated killer induction from blood mononuclear cells