◀ Back to IL10
IL10 — NOX1
Text-mined interactions from Literome
Tojo et al., J Hypertens 2005
(Hypertension, Renal) :
Nicotinamide adenine dinucleotide phosphate (
NAD ( P ) H ) oxidase is
regulated by angiotensin II,
interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Perianayagam et al., Eur J Clin Invest 2005
(Uremia) :
In contrast, apocynin, a selective
NADPH oxidase inhibitor, did not
inhibit ET-stimulated
IL-10 production
Dang et al., FASEB J 2006
:
This
IL-10 effect could
contribute to the tight regulation of
NADPH oxidase activity at the inflammatory site
Kassan et al., Arterioscler Thromb Vasc Biol 2011
(Disease Models, Animal...) :
These data demonstrate that
IL-10 released from Tregs
attenuates NADPH oxidase activity, which is a critical process in the improvement of microvascular endothelial function in hypertension, suggesting that Tregs/IL-10 could be a therapeutic target for treatment of vasculopathy in hypertension
Dammanahalli et al., J Hypertens 2011
:
IL-10KO increased Nox1 protein expression,
NADPH oxidase activity, and superoxide production in aortas