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APC — NOTCH1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Presenilin action in Notch and Wnt signaling: NOTCH1 Precursor (NOTCH1) → APC (APC) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 50 proteins (colocalization, proximity-dependent biotin identification)