Gene interactions and pathways from curated databases and text-mining

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DTX1 — NOTCH1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Yamamoto et al., J Biol Chem 2001 : We show that Deltex-1 (DTX1) , a mammalian homolog of Drosophila Deltex, mediates a Notch signal to block differentiation of neural progenitor cells
Endo et al., Dev Growth Differ 2003 : Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development
Höflinger et al., J Immunol 2004 : At the same time, Notch signaling rapidly induces cell surface expression of the c-Kit receptor and transcription of the target genes Deltex1 and pre-Talpha concomitant with the activation of TCR Vbeta germline transcription and the regulatory genes GATA3 and Tcf1
Hu et al., Dev Neurosci 2006 : Remarkably, all these F3 and NB-3/Notch cascade related events required Deltex1 as the intermediate element
Lehar et al., Mol Cell Biol 2006 : Deltex1 is highly induced by Notch signaling in thymocytes, and overexpression of Deltex1 in T-cell progenitors can block Notch signals, suggesting that Deltex1 may play an important role in regulating Notch signals during T-cell development
Jundt et al., Leukemia 2008 (Hodgkin Disease) : We provide evidence that absence of the Notch inhibitor Deltex1 contributes to deregulated Notch activity in Hodgkin and Reed-Sternberg cells
Van de Walle et al., Blood 2009 : High Notch activity increases DTX1 , NRARP, and RUNX3 expression, genes that are down-regulated during alphabeta-lineage differentiation
Zhang et al., Oncogene 2010 (Bone Neoplasms...) : Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness ... The inhibitory effect of endogenous Deltex1 on NOTCH signaling is mediated through binding with the intracellular domain of NOTCH and ubiquitination and degradation of NOTCH receptors
Huber et al., PloS one 2013 : Over-expression of DTX1 increased cell migration and invasion correlating to ERK activation, miR-21 levels and endogenous Notch levels