◀ Back to NOTCH1

NOTCH1 — SETD2

Text-mined interactions from Literome

Wang et al., FASEB J 2006 : Our results demonstrate that APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by HIF-1 , and the specific control of APH-1A expression may imply physiological functions uniquely assigned to APH-1A
Lawton et al., Oxidative medicine and cellular longevity 2010 : We found that : 1 ) AAH, HIF-1a , and neuronal migration were stimulated by H2O2; 2 ) si-HIF-1a reduced AAH expression and cell motility ; 3 ) si-AAH inhibited Notch and cell migration, but not HIF-1a ; and 4 ) si-Notch-1 increased FIH and inhibited HIF-1a ... We found that : 1 ) AAH, HIF-1a , and neuronal migration were stimulated by H2O2; 2 ) si-HIF-1a reduced AAH expression and cell motility ; 3 ) si-AAH inhibited Notch and cell migration, but not HIF-1a ; and 4 ) si-Notch-1 increased FIH and inhibited HIF-1a
Lam et al., Cell stem cell 2011 : Wang et al. ( 2011 ) report that hypoxia-inducible factor 1a (HIF1a) represses Notch signaling to maintain CSC subsets from lymphoma, and that blocking HIF1a activity eliminates lymphoma and human acute myeloid leukemia ( AML ) CSCs
Zou et al., Journal of hematology & oncology 2013 (Neoplasm Invasiveness...) : Hypoxia/HIF-1a activated Notch1 signalling altered expression of cell cycle regulatory proteins and accelerated cell proliferation