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IFNG — PSMB10
Text-mined interactions from Literome
van Hall T et al., J Exp Med 2000
:
Interferon (IFN)-gamma induces expression of three catalytically active proteasome subunits ( LMP2, LMP7, and
MECL-1 ) and the proteasome associated activator PA28
Groettrup et al., Eur J Immunol 1996
:
We compared the 20S proteasome subunit pattern from IFN-gamma induced and non induced mouse fibroblasts on two-dimensional gels and identified a third subunit exchange by microsequencing : the non-MHC encoded subunit
MECL-1 is
induced by
IFN-gamma and replaces a sofar barely characterized beta subunit designated ` MC14 '
Nandi et al., J Immunol 1996
(Liver Neoplasms, Experimental) :
MECL-1 transcription is increased in the
presence of
IFN-gamma , whereas the transcription of two other proteasome genes, Lmp-15 and Lmp-3, is not affected
Foss et al., Biochim Biophys Acta 1998
(Adenocarcinoma...) :
To reveal the extent of constitutive and
IFN-gamma induced expression of
MECL1 , we studied MECL1 in different cell lines by Northern and Western blotting ... The two B cell lines IM9 and Reh showed high constitutive expression of
MECL1 , only slightly
induced by
IFN-gamma stimulation ... The
MECL1 protein level in the THP-1 cells increased markedly in
response to
IFN-gamma ... These results indicate that, similar to LMP2 and LMP7,
MECL1 is constitutively expressed at high levels only in certain cell lines and can be
induced by
IFN-gamma in other cell lines