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IFIT1 — IL2

Text-mined interactions from Literome

Taichman et al., Cytokine 1992 : CTLL-2 and HT-2 LCK- and LCK ( Y505F ) -transfected cells remained dependent on IL-2 for their growth and survival in culture despite the findings that ( i ) IL-2 specifically stimulated elevations in the activity of the endogenous p56-LCK in untransfected CTLL-2 cells without affecting the activities of the other SRC-like kinases in these cells ( p59-FYN, p62-YES ) and that ( ii ) IL-2 mediated regulation of p56-LCK correlated with IL-2-driven proliferation of these T cells
Granelli-Piperno et al., J Autoimmun 1992 : A member of the src gene family, the lymphocyte-specific protein tyrosine kinase, p56lck , has been implicated in IL-2 production
Torigoe et al., Leukemia 1992 : In contrast to IL-2 's effects on p56-LCK in T-cells, studies of an IL-2-responsive cell line of the B-cell lineage that lacks p56-LCK revealed that IL-2 specifically regulates the activity of the p53/56-LYN kinase ... This finding that p53/56-LYN can be regulated by both IL-2 in B-lineage cells and IL-3 in myeloid committed cells demonstrates that the same SRC-family PTK can participate in signal transduction events mediated via two independent receptor systems
Saito et al., J Biol Chem 1991 : A similar lysate mixing experiment also showed that p56 is involved in IL-2 binding to the high affinity IL-2 receptor by forming the quaternary complex of IL-2, p56, L chain, and H chain
Wathelet et al., Eur J Biochem 1987 : We found that poly ( rI ) .poly ( rC ) and interleukin-1 , activators of the interferon-beta gene and of T lymphocytes respectively, are both able to enhance IFI-56K mRNA accumulation in all cell lines tested