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NANOG — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lin et al., Nat Cell Biol 2005
:
p53 binds to the promoter of Nanog, a gene required for ESC self-renewal, and
suppresses Nanog expression after DNA damage
Han et al., Cell stem cell 2008
:
SIRT1
regulates apoptosis and
Nanog expression in mouse embryonic stem cells by controlling
p53 subcellular localization ... Endogenous ROS triggered apoptosis of wild-type mES through mitochondrial translocation of p53 and BAX but inhibited Nanog expression of SIRT1 ( -/- ) mES, indicating that SIRT1 makes mES cells sensitive to ROS and inhibits
p53 mediated suppression of
Nanog expression
Susanto et al., PloS one 2008
:
The increased level of
p53 reduced
Nanog expression because RNA- interference mediated inhibition of p53 was able to prevent the downregulation of Nanog induced by FTC treatment
Baltus et al., J Biol Chem 2009
:
Our data demonstrate that the mSin3A-HDAC complex can positively regulate Nanog expression under proliferating conditions and that this activity is complementary to mSin3A mediated
p53 dependent silencing of
Nanog during differentiation
Po et al., EMBO J 2010
(Medulloblastoma) :
Conversely, Hh downregulates
p53 but does not
require p53 to control
Nanog
Calvanese et al., Proc Natl Acad Sci U S A 2010
:
The longevity promoting NAD+ dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the
p53 dependent expression of
NANOG
Campbell et al., Stem Cells Dev 2012
:
When active, GSK3 and
p53 block the transcription of
Nanog , which is important for maintaining pluripotency
Abdelalim et al., Biochem Biophys Res Commun 2012
:
In addition, inhibition of
p53 activity
reduced the expression levels of cyclin D1 and
Nanog
Hadjal et al., Cell death & disease 2013
:
Use of anti-Nanog siRNAs demonstrates that certain of these regulations result partially to
p53 dependent repression of
Nanog gene expression