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IL8 — LPA

Text-mined interactions from Literome

Schwartz et al., Gynecol Oncol 2001 (Ovarian Neoplasms) : We describe here that LPA , S1P, and SPC increased mRNA levels ( 2- to 7-fold ) and protein secretion ( 2- to 12-fold ) of IL-8 from ovarian cancer cells ( HEY, OCC1, and SKOV3 ) in vitro ... LPA , S1P, and SPC regulate the mRNA and protein levels of the proinflammatory and proangiogenic factor IL-8 in ovarian cancer cells
Klezovitch et al., J Biol Chem 2001 : A monoclonal antibody specific for Kringle V inhibited the apo(a) mediated effect on IL-8 ... We conclude that Lp(a) via elements contained in the C-terminal domain of apo(a) causes in THP-1 macrophages an increased production of IL-8 , a chemokine with pro-inflammatory properties, an event that may be relevant to the process of atherosclerosis
Shida et al., Cancer Res 2003 (Colonic Neoplasms...) : Furthermore, LPA stimulated DLD1 cell adhesion to collagen type I ( 2.0-fold increase at 10 microM ) and also stimulated the secretion of both vascular endothelial growth factor ( 1.4-fold increase at 20 microM ) and interleukin 8 ( 19-fold increase at 20 microM ) by ELISA
Tanyi et al., Clin Cancer Res 2003 (Ovarian Neoplasms) : LPA stimulates cell proliferation, cell survival, resistance to cisplatin, production and activation of proteases, invasiveness and production of the neovascularizing factors, vascular endothelial growth factor, and interleukin 8
Fang et al., J Biol Chem 2004 (Ovarian Neoplasms) : In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells ... LPA stimulated the transcriptional activity of the IL-8 gene with little effect on IL-8 mRNA stability ... The optimal response of the IL-8 gene promoter to LPA relied on binding sites for NF-kappaB and AP-1, two transcription factors that were strongly activated by LPA in ovarian cancer cell lines ... Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines ... These studies elucidate the transcriptional mechanism and the Edg LPA receptors involved in LPA induced IL-6 and IL-8 production and suggest potential strategies to restrain the expression of these cytokines in ovarian cancer
Cummings et al., J Biol Chem 2004 (Inflammation) : Here, we report that protein kinase Cdelta (PKCdelta) mediates LPA induced NF-kappaB transcription and interleukin-8 (IL-8) secretion in HBEpCs ... Furthermore, LPA activated PKCdelta and the LPA mediated activation of NF-kappaB and IL-8 production were attenuated by overexpression of dominant negative PKCdelta and rottlerin
Yun et al., Am J Physiol Cell Physiol 2005 (Colonic Neoplasms) : LPA also induced interleukin-8 (IL-8) synthesis in the colon cancer cells by primarily activating LPA2 receptor
Saatian et al., Biochem J 2006 : We have recently demonstrated that LPA ( lysophosphatidic acid ) stimulated IL-8 production in HBEpCs via protein kinase C delta dependent signal transduction ... The LPA induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA ( small interfering RNA ), and by the JNK inhibitor JNK ( i ) II, but not by the MEK ( MAPK/ERK kinase ) inhibitor, PD98059 ... LPA enhanced the transcriptional activity of the IL-8 gene ; that effect relied on activation of the transcriptional factors NF-kappaB ( nuclear factor kappaB ) and AP-1 ( activator protein-1 ) ... Additionally, siRNA for LPA ( 1-3 ) receptors partially blocked LPA induced IL-8 production and activation of MAPKs ... The LPA1 and LPA3 receptors, as compared with LPA2, were most efficient in transducing LPA mediated IL-8 production ... These results show an independent role for p38 MAPK and JNK in LPA induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs
Mori et al., J Surg Res 2006 (Colonic Neoplasms) : Then, we investigated LPA induced migration and IL-8 secretion in DLD1 cells ... LPA induced significant migration and IL-8 secretion in DLD1, both of which were significantly inhibited by AG1478 or GM6001
Zhao et al., J Biol Chem 2006 : We have demonstrated earlier that lysophosphatidic acid (LPA) induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta) dependent NF-kappaB activation in human bronchial epithelial cells ( HBEpCs ) ... These results demonstrate that LPA induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta dependent activation of Lyn kinase and MMPs and proHB-EGF shedding, suggesting a novel mechanism of cross-talk and interaction between G-protein coupled receptors and receptor-tyrosine kinases in HBEpCs
Lin et al., J Cell Biochem 2006 : Work illustrated in this article showed that LPA and S1P enhanced IL-8 and MCP-1 mRNA expressions, and protein secretions in dose- and time dependent fashions
Lin et al., Biochem Biophys Res Commun 2007 (Inflammation) : Moreover, LPA1 and LPA3 siRNA also inhibited LPA enhanced IL-1 dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA treated HUVEC conditioned media
Zhao et al., Mol Pharmacol 2008 (Arthritis, Rheumatoid) : Moreover, exogenously applied LPA induces FLS migration and secretion of IL-8/IL-6 , whereas the LPA ( 3 ) agonist l-sn-1-O-oleoyl-2-methyl-glyceryl-3-phosphothionate ( 2S-OMPT ) stimulates cytokine synthesis but not cell motility
Chen et al., Endocrinology 2008 : The effects of LPA on the expression of vascular endothelial growth factor, IL-6, and IL-8 were examined ... LPA enhanced IL-8 expression in a dose- and time dependent manner, whereas vascular endothelial growth factor or IL-6 expression was not affected by LPA treatment ... LPA induced IL-8 enhanced migration, permeability, capillary tube formation, and proliferation of human endometrial microvascular endothelial cells ... Through the LPA1 receptor, LPA induces IL-8 expression via a nuclear factor-kappaB dependent signal pathway
Gustin et al., Am J Physiol Cell Physiol 2008 : Using Ki16425 ( an LPA ( 1 ) and LPA ( 3 ) receptor antagonist ), GW9662 [ a peroxisome proliferator-activator receptor ( PPARgamma ) antagonist ], and pertussis toxin ( that inhibits G ( i/o ) ), we demonstrate that LPA enhances IL-8 and monocyte chemoattractant protein-1 expression through a LPA ( 1 ) -, LPA ( 3 ) -, G ( i/o ) - and PPARgamma dependent manner in the EAhy926 cells
Kalari et al., Am J Physiol Lung Cell Mol Physiol 2009 (MAP Kinase Signaling System) : Role of acylglycerol kinase in LPA induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells ... Here, we investigated signaling pathways of IL-8 secretion mediated by AGK and intracellular LPA in human bronchial epithelial cells ( HBEpCs ) ... Overexpression of lentiviral AGK wild type increased intracellular LPA production ( approximately 1.8-fold ), enhanced LPA mediated IL-8 secretion, and stimulated tyrosine phosphorylation epidermal growth factor-receptor (EGF-R) ... Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold ) and attenuated LPA induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion ... These results suggest that native AGK regulates LPA mediated IL-8 secretion involving MAPKs, NF-kappaB, and transactivation of EGF-R
Shimada et al., FEBS Lett 2010 : In this study, LPA activated ROCK, p38, JNK and NF-kappaB pathways and induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) mRNA and protein expression in human endothelial cells
Chen et al., Int J Cancer 2012 (Neovascularization, Pathologic...) : Finally, we evaluated the regulation pathways involved in LPA induced IL-8 expression
Mu et al., Am J Pathol 2012 (Lymphatic Metastasis...) : In addition, LPA induces IL-8 expression by enhancing IL-8 promoter activity via activation of the NF-?B pathway in LECs ... Moreover, using siRNA inhibition, we discovered that LPA induced lymphangiogenesis in vitro and IL-8 production are mediated via the LPA ( 2 ) receptor in LECs ... These studies provide the first evidence that LPA promotes lymphangiogenesis and induces IL-8 production in LECs ; we also reveal a possible new role of LPA in the promotion of tumor progression, as well as metastasis, in different cancer types
Wooten et al., J Immunol 1998 : Lipoprotein mediated induction of nuclear factor-kappaB nuclear translocation and production of IL-8 and IL-6 in HUVEC was enhanced in the presence of serum or soluble rCD14