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IFNG — IL1RN
Text-mined interactions from Literome
Danis et al., Clin Exp Immunol 1995
:
This was especially evident when cytokines were used in combination with GM-CSF :
IFN-gamma down-regulated production of
IL-1Ra while up-regulating the production of IL-1 alpha/beta, IL-6 and TNF-alpha, while IL-4 had the exact opposite effect
Re et al., Eur J Immunol 1993
:
Secretion of
IL-1ra was
induced in PMN treated with LPS, IL-4 and GM-CSF, but not by IL-1 beta,
IFN-gamma and fMLP, thus yielding results that paralleled those seen in Northern blot experiments
Ruth et al., J Immunol 1996
(Granuloma) :
In vivo depletion of IL-4, IL-10, IL-12, IFN-gamma, or TNF-alpha with 5 mg of cytokine-specific neutralizing rabbit IgG revealed that
IFN-gamma and TNF-alpha were
required for maximal
IL-1ra production by Mphi
Gasperini et al., AIDS 1998
(HIV Infections) :
In contrast, release of IL-1beta and
IL-1ra ( IL-1 receptor antagonist ) in
response to LPS, or LPS plus
IFNgamma , was found to be lower in PMN from HIV positive patients than in PMN from controls, but was significant only in the case of IL-1ra
Kovalovsky et al., Eur J Immunol 1998
:
In the present work we examined the
regulation of
IL-1Ra by Th1 cytokine
IFN-gamma , Th2 cytokine IL-4, glucocorticoids and IL-1 in human monocytes
Liu et al., J Immunol 1998
:
However,
IFN-gamma also
suppresses the expression of IFN-beta- and IL-4 induced
IL-1Ra so that IFN-gamma may enhance or suppress IL-1 activity depending on the other cytokines present