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SPP1 — UTP20

Text-mined interactions from Literome

Chaulet et al., Circ Res 2001 : In parallel, UTP increased osteopontin expression dose-dependently ... Moreover, the blockade of ERK-1/ERK-2 MAP kinase or rho protein pathways led to the inhibition of both UTP induced osteopontin increase and migration, demonstrating the central role of osteopontin in this process
Seye et al., Circulation 2002 (Carotid Stenosis...) : ATP or UTP also stimulated osteopontin expression in cultured SMCs in a dose dependent manner ... Furthermore, P2Y2 antisense oligonucleotide inhibited osteopontin expression induced by UTP
Renault et al., Arch Mal Coeur Vaiss 2003 : [ Mechanisms of regulation of osteopontin expression mediated by UTP , angiotensin II and PDGF in arterial smooth muscle cells ]
Renault et al., Circ Res 2003 : AP-1 is involved in UTP induced osteopontin expression in arterial smooth muscle cells ... Moreover, we recently demonstrated that the extracellular nucleotide UTP also induces OPN expression and that OPN is essential for UTP mediated SMC migration ... First, we explored the contribution of mRNA stabilization and transcription in the increase of UTP induced OPN mRNA levels ... Then, to identify transcription factors involved in UTP induced OPN transcription, we located a promoter element activated by UTP within the rat OPN promoter using a gene reporter assay strategy ... The -96 to +1 region mediated UTP induced OPN overexpression ( +276+/-60 % ) ... Thus, this AP-1 ( -76 ) site is involved in UTP induced OPN transcription
Renault et al., J Biol Chem 2005 : UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells ... Using dominant negative mutants of IkappaB kinase and USF transcription factors, we confirmed that NFkappaB and USF-1/USF-2 are involved in the UTP mediated expression of OPN ... Finally, our work suggests that the UTP stimulated OPN expression involves a coordinate regulation of PKCdelta-NFkappaB, ERK1/2-USF, and ERK1/2/NAD ( P ) H oxidase AP-1 signaling pathways
Jalvy et al., Circ Res 2007 (MAP Kinase Signaling System) : The present study aims to determine the role of CREB in UTP induced migration and OPN expression in cultured SMCs ... Both overexpression of a dominant negative CREB and CREB small interfering RNA treatment suppressed UTP induced OPN expression and SMC migration ... Mutations of these sites showed that only the 2 AP-1 sites were required for UTP induced OPN expression ... These results demonstrate that CREB participates in the induction of UTP activated OPN expression via its binding to 2 AP-1 sites and is thus involved in UTP mediated SMC migration