Gene interactions and pathways from curated databases and text-mining

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CA2 — NOX5

Text-mined interactions from Literome

Bánfi et al., J Biol Chem 2004 : Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)
Oommen et al., Biochem Pharmacol 2004 : CA also inhibited the store operated influx of Ca2+ into control neutrophils treated with 1 microM thapsigargin, a selective inhibitor of the endomembrane Ca2+-ATPase , which does not activate NADPH oxidase
Cheranov et al., Am J Physiol Cell Physiol 2006 (Calcium Signaling) : TNF-alpha dilates cerebral arteries via NAD ( P ) H oxidase dependent Ca2+ spark activation
Mayer et al., FEBS Lett 1991 : We found that the purified enzyme also contains FAD, FMN and non-heme iron in equimolar amounts and exhibits striking activities, including a Ca2+/calmodulin dependent NADPH oxidase activity, leading to the formation of hydrogen peroxide at suboptimal concentrations of L-arginine or H4biopterin
Potocký et al., New Phytol 2007 : Exogenous CaCl2 increased NBT reduction at the pollen tube tip, suggesting that Ca2+ increases the activity of pollen NOX in vivo
Takeda et al., Science 2008 : We found that Ca2+ , in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair
Glian'ko et al., Prikl Biokhim Mikrobiol 2013 : It is concluded that Ca2+ and reactive oxygen species are involved in the regulation of the membrane NADPH oxidase activity in roots of pea seedlings
Rossi et al., J Immunol 1989 : These findings indicate that the activation of phosphoinositide turnover, the liberation of arachidonic acid, the rise in [Ca2+ ] i, and the activity of protein kinase C are not necessarily required for ingestion of Con A-opsonized particles and for associated activation of the NADPH oxidase , the enzyme responsible for the respiratory burst
Sakata et al., Biochem Biophys Res Commun 1987 : The calmodulin inhibitor, N- ( 6-aminohexyl ) -5-chloro-1-naphthalene sulfonamide ( W-7 ), or trifluoperazine inhibited not only Fc gamma-receptor mediated cytosolic free Ca2+ increase and O2- generation in macrophages, but also an arachidonate induced activation of NADPH-oxidase in a cell-free system
Suzuki et al., J Biol Chem 1985 : Enhancement by Ca2+ or Mg2+ of catalytic activity of the superoxide producing NADPH oxidase in membrane fractions of human neutrophils and monocytes
Aviram et al., FEBS Lett 1983 : Activation of NAD ( P ) H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca2+
Torres et al., Plant J 1998 : A putative EF-hand Ca ( 2+ ) -binding motif in the extended N-terminal region of the Atrboh proteins suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants
Watson et al., Biochem Biophys Res Commun 1998 : Stimulation of primed neutrophils by soluble immune complexes : priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase