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PTPN11 — STAT5A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of GAB2-PTPN11-STAT5A → IL2 (increases)
  Evidence: We show that Gab2 was transiently phosphorylated by tyrosine in human mycosis fungoides (MF) tumor T cells upon IL-2 stimulation and that SHP2 as well as Stat5a associated inducibly with Gab2. IL-15, but not IL-4, also induced tyrosine phosphorylation of Gab2, suggesting that the IL-2 receptor beta-chain is important for IL-2-induced Gab2 phosphorylation.
• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTPN11 — STAT5A (direct interaction, enzymatic study) Yu et al., J Biol Chem 2000*
• IRef Biogrid Interaction: PTPN11 — STAT5A (direct interaction, pull down) Yu et al., J Biol Chem 2000*
• IRef Biogrid Interaction: PTPN11 — STAT5A (physical association, affinity chromatography technology) Chughtai et al., J Biol Chem 2002*
• IRef Hprd Interaction: PTPN11 — STAT5A (in vitro) Yu et al., J Biol Chem 2000*, Chughtai et al., J Biol Chem 2002*, Espanel et al., Protein Sci 2002*
• IRef Hprd Interaction: PTPN11 — STAT5A (in vivo) Yu et al., J Biol Chem 2000*, Chughtai et al., J Biol Chem 2002*, Espanel et al., Protein Sci 2002*
• IRef Ophid Interaction: STAT5A — PTPN11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Itoh et al., J Allergy Clin Immunol 1999 : Adding back each tyrosine to Fall revealed that ( 1 ) Tyr577 was necessary and sufficient for Shc phosphorylation ; ( 2 ) Tyr577, Tyr612, and Tyr695 were involved in activation of SHP-2 , the Raf/ERK cascade, and c-fos transcription ; and ( 3 ) all tyrosines, but particularly Tyr612, Tyr695, Tyr750, and Tyr806, facilitated STAT5 activation
Yu et al., J Biol Chem 2000 (Lymphoma, T-Cell) : Potential role of SHP-2 in STAT5 regulation
Lundin Brockdorff et al., Cytokine 2002 (MAP Kinase Signaling System...) : SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells ... Furthermore, the results indicate that SHP2 may not be involved in the activation of Stat3 or Stat5 in CTCL cells
Ke et al., J Biol Chem 2006 : Paradoxically, cell culture studies also suggest a positive role of Shp2 in promoting prolactin stimulated Stat5 activation
Yuan et al., J Biol Chem 2010 (Breast Neoplasms...) : Furthermore, PTPN9 WT expression specifically impairs EGF induced STAT3 and STAT5 activation, and inhibits the cell growth in soft agar
Li et al., Blood 2011 : A critical role for SHP2 in STAT5 activation and growth factor mediated proliferation, survival, and differentiation of human CD34+ cells ... Inhibition of SHP2 expression initially enhanced and later inhibited STAT5 phosphorylation and reduced expression of the antiapoptotic genes MCL1 and BCLXL ... These results indicate an important role for SHP2 in STAT5 activation and GF-mediated proliferation, survival, and differentiation of human progenitor cells