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AURKA — TPX2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Aurora A signaling: Aurora A/TPX2 complex (AURKA-TPX2) → TPX2 (TPX2) (modification, collaborate) Kufer et al., J Cell Biol 2002*, Tsai et al., Nat Cell Biol 2003*, Bayliss et al., Mol Cell 2003*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Aurora A signaling: Aurora A/TPX2 complex (AURKA-TPX2) → Aurora A (AURKA) (modification, collaborate) Kufer et al., J Cell Biol 2002*, Tsai et al., Nat Cell Biol 2003*, Bayliss et al., Mol Cell 2003*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Aurora A signaling: TPX2 (TPX2) → Aurora A (AURKA) (modification, collaborate) Kufer et al., J Cell Biol 2002*, Tsai et al., Nat Cell Biol 2003*, Bayliss et al., Mol Cell 2003*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Aurora A signaling: Aurora A/TPX2 complex (AURKA-TPX2) → HURP (DLGAP5) (spindle assembly, collaborate) Kufer et al., J Cell Biol 2002*, Tsai et al., Nat Cell Biol 2003*, Yu et al., Mol Cell Biol 2005*, Koffa et al., Curr Biol 2006*
  Evidence: mutant phenotype, assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AURKA — TPX2 (physical association, affinity chromatography technology) Katayama et al., Cell cycle (Georgetown, Tex.) 2008*
• IRef Biogrid Interaction: AURKA — TPX2 (direct interaction, pull down) Trieselmann et al., J Cell Sci 2003*
• IRef Biogrid Interaction: AURKA — TPX2 (physical association, affinity chromatography technology) Hutchins et al., Science 2010
• IRef Biogrid Interaction: AURKA — TPX2 (physical association, affinity chromatography technology) Maxwell et al., PLoS Biol 2011*
• IRef Biogrid Interaction: AURKA — TPX2 (physical association, affinity chromatography technology) Fu et al., Proc Natl Acad Sci U S A 2009*
• IRef Biogrid Interaction: AURKA — TPX2 (physical association, affinity chromatography technology) Kufer et al., J Cell Biol 2002*
• IRef Biogrid Interaction: AURKA — TPX2 (direct interaction, pull down) Kufer et al., J Cell Biol 2002*
• IRef Dip Interaction: Complex of AURKA-AURKA-BRCA1-TPX2-TPX2-HMMR-BRCA1-HMMR (anti bait coimmunoprecipitation) Maxwell et al., PLoS Biol 2011*
• IRef Dip Interaction: Complex of HMMR-TPX2-AURKA (anti bait coimmunoprecipitation) Maxwell et al., PLoS Biol 2011*
• IRef Dip Interaction: Complex of TPX2-BRCA1-HMMR-BARD1-AURKA (anti bait coimmunoprecipitation) Maxwell et al., PLoS Biol 2011*
• IRef Dip Interaction: AURKA — TPX2 (physical association, anti bait coimmunoprecipitation) Maxwell et al., PLoS Biol 2011*
• IRef Dip Interaction: AURKA — TPX2 (physical association, anti tag coimmunoprecipitation) Fu et al., Proc Natl Acad Sci U S A 2009*
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Irelan et al., Proc Natl Acad Sci U S A 2007
• IRef Hprd Interaction: AURKA — TPX2 (in vitro) Kufer et al., J Cell Biol 2002*, Bayliss et al., Mol Cell 2003*
• IRef Hprd Interaction: AURKA — TPX2 (in vivo) Kufer et al., J Cell Biol 2002*, Bayliss et al., Mol Cell 2003*
• IRef Intact Interaction: Complex of TPX2-AURKA-CEP192-AURKA-CALU (physical association, tandem affinity purification) Hutchins et al., Science 2010
• IRef Intact Interaction: AURKA — TPX2 (direct interaction, x-ray crystallography) Bayliss et al., Mol Cell 2003*
• IRef Ophid Interaction: AURKA — TPX2 (aggregation, confirmational text mining) Kufer et al., J Cell Biol 2002*
• IRef Ophid Interaction: AURKA — TPX2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Mohan et al., Oncotarget 2013 (Nerve Sheath Neoplasms) : Silencing of HMMR/RHAMM, but not TPX2 , augments AURKA activity and sensitizes MPNST cells to AKI
Li et al., Mol Oncol 2013 : Inhibition of AURKA and TPX2 using siRNA mimicked enforced GLIPR1 expression in the induction of apoptosis and MC. Recombinant GLIPR1-dTM protein inhibited AURKA and TPX2 expression, induced apoptosis and MC, and suppressed orthotopic xenograft tumor growth