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AHR — PTGS2

Text-mined interactions from Literome

Regala et al., Mar Environ Res 2004 : For example, iNOS, COX-2 , and CYP1A are induced by both inflammation and AhR ligands
Chang et al., Carcinogenesis 2007 : Third, although the aryl hydrocarbon receptor (AhR) did not play a role in BaP induced COX-2 expression, the potentiation effect of E ( 2 ) itself was AhR dependent
Fritsche et al., Proc Natl Acad Sci U S A 2007 : Specifically, AhR activation by UVB leads to ( i ) transcriptional induction of cytochrome P450 1A1 and ( ii ) EGF receptor internalization with activation of the EGF receptor downstream target ERK1/2 and subsequent induction of cyclooxygenase-2
Degner et al., J Nutr 2009 (Breast Neoplasms) : Targeting of aryl hydrocarbon receptor mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells ... Because the activation of cyclooxygenase-2 (COX-2) expression by AhR ligands may contribute to inflammation and tumorigenesis, we investigated the epigenetic regulation of the COX-2 gene by TCDD and the reversal effects of DIM in MCF-7 breast cancer cells
Puga et al., Biochem Pharmacol 1997 (Liver Neoplasms, Experimental) : Induction of Cox-2 is in fact dependent on the presence of a functional Ah receptor , since it can be blocked by antisense oligonucleotides to Ah receptor mRNA
Vogel et al., Arch Biochem Biophys 1998 : The main aim of this study was to examine whether PGHS-2 mRNA expression can be changed by acute TCDD in vivo and, second, we were also interested in whether modulation of PGHS-2 is mediated by the aryl hydrocarbon receptor (AhR) which is known to be involved in the transcriptional control of TCDD induced phase 1 and phase 2 enzymes