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IL17A — NFKB1

Text-mined interactions from Literome

Awane et al., J Immunol 1999 : IL-17 induced NF-kappa B protein-DNA complexes consisting of p65/p50 heterodimers in the rat intestinal epithelial cell line IEC-6 ... In addition to activation of the NF-kappa B , IL-17 regulated the activities of extracellular regulated kinase, c-Jun N-terminal kinase, and p38 mitogen activated protein kinases in IEC-6 cells
Schwandner et al., J Exp Med 2000 : Here we report the requirement of tumor necrosis factor receptor associated factor ( TRAF)6 in IL-17 induced NF-kappaB and JNK activation ... Lack of TRAF6 appeared to be the sole defect responsible for the observed failure to respond to IL-17, because transient transfection of TRAF6 expression plasmid into the TRAF6-deficient cells restored IL-17 induced NF-kappaB activation in a luciferase reporter assay
Andoh et al., Clin Exp Immunol 2001 : IL-17 rapidly induced the phosphorylation and degradation of I kappa B alpha molecules, and the combination of IL-17 and IFN-gamma induced a marked increase in NF-kappa B DNA binding activity as early as 1.5 h after the stimulation
Shimada et al., J Immunol 2002 : EMSAs demonstrated that IL-17 , IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha induced IL-6 gene expression
Takaya et al., Scand J Gastroenterol 2002 : Furthermore, IL-17 induced a rapid increase in NF-kappaB DNA binding activity, and the combination of IL-17 and IFN-gamma further enhanced NF-kappaB DNA binding activity
Hata et al., Am J Physiol Gastrointest Liver Physiol 2002 (Inflammatory Bowel Diseases) : IL-17 induced NF-kappaB activation within 45 min after stimulation
Kim et al., Arthritis Res Ther 2005 (Arthritis, Rheumatoid...) : IL-17 production by activated RA PBMC is completely or partly blocked in the presence of the NF-kappaB inhibitor pyrrolidine dithiocarbamate and the PI3K/Akt inhibitor wortmannin and LY294002, respectively
Schnyder et al., Cytokine 2005 : IL-17 also inhibited the TNF mediated expression of adhesion molecule VCAM-1, and the NF-kappaB binding to the VCAM-1 promoter-specific site, along with the inhibitor of NF-kappaB, IkappaB-beta
Kanda et al., J Allergy Clin Immunol 2005 : IL-17 suppressed TNF-alpha induced CCL27 secretion and mRNA expression and NF-kappaB activity in keratinocytes
Henness et al., Am J Physiol Lung Cell Mol Physiol 2006 (Lung Neoplasms) : As IL-17A had no effect on the activity of NF-kappaB , a key transcriptional regulator of IL-8 gene expression, we then examined whether IL-17A acts at the posttranscriptional level
Shen et al., J Biol Chem 2006 : These findings were strikingly similar to the IL-6 promoter, where IL-17 mediated regulation of both NF-kappaB and C/EBP is essential
Chang et al., J Biol Chem 2006 (Inflammation...) : An earlier study found that IL-17 activates NF-kappaB and MAPK pathways and requires TRAF6 to induce IL-6
Cho et al., Immunol Lett 2007 (Arthritis, Rheumatoid) : Moreover PI3K/Akt inhibitor, NF-kappaB inhibitor, and FK506 significantly inhibited IL-15 induced IL-17 production in CD4+ T cells
Witowski et al., Kidney Int 2007 : The novel observation was that IL-17A stimulated NF-kappaB activation in HPMCs followed a biphasic profile, with an early induction ( 45 min ), followed by the return to basal levels ( 90 min ), and a delayed induction ( 3 h )
Patel et al., J Biol Chem 2007 : IL-17 induced CRP promoter-driven reporter gene activity that could be attenuated by dominant negative IkappaBalpha or C/EBPbeta knockdown and stimulated both NF-kappaB and C/EBP DNA binding and reporter gene activities
Cortez et al., Am J Physiol Heart Circ Physiol 2007 : IL-17 stimulated activator protein-1 [ AP-1 ( c-Fos, c-Jun, and Fra-1 ) ], NF-kappaB ( p50 and p65 ), and CCAAT enhancer binding protein (C/EBP)-beta DNA binding and reporter gene activities, effects attenuated by antisense oligonucleotides, siRNA mediated knockdown, or expression of dominant negative signaling proteins
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Paradowska et al., Arch Immunol Ther Exp (Warsz) 2007 (Arthritis, Rheumatoid) : IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells triggers the activation of transcription factor NF-kappaB and mitogen activated protein kinase ( p-38 ), which in turn results in the secretion of IL-1, TNF-alpha, IL-6, IL-8, or prostaglandin E2
Park et al., J Immunol 2009 (Asthma...) : In addition, we found that administration of rosiglitazone or pioglitazone decreased the increased NF-kappaB activity and that a NF-kappaB inhibitor, BAY 11-7085, substantially reduced the increased IL-17 protein levels in the lung tissues after OVA inhalation
Xie et al., J Immunol 2010 : Knockdown of TNFR associated factor 6 or NF-kappaB activator 1 in 70Z/3 pre-B cells led to decreased Rgs16 expression, indicating that both of these two genes are involved in IL-17 mediated activation of NF-kappaB signaling in B cells
Adamopoulos et al., Arthritis Res Ther 2010 : Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors ... IL-17A upregulates the receptor activator for NF-kappaB receptor on human osteoclast precursors in vitro, leading to increased sensitivity to RANKL signalling, osteoclast differentiation and bone loss
Segal et al., PloS one 2010 (Granulomatous Disease, Chronic...) : When challenged with either intratracheal zymosan or LPS, NADPH oxidase-deficient p47 ( phox-/- ) mice and gp91(phox)-deficient mice developed exaggerated and progressive lung inflammation, augmented NF-kappaB activation , and elevated downstream pro-inflammatory cytokines ( TNF-alpha, IL-17 , and G-CSF ) compared to wildtype mice
Sønder et al., J Biol Chem 2011 : IL-17 induced NF-kappaB activation via CIKS/Act1 : physiologic significance and signaling mechanisms
Tyagi et al., PloS one 2012 (Osteoporosis) : E2 treatment to mouse calvarial osteoblasts inhibited the IL-17 induced production of osteoclastogenic cytokines and NF-kB translocation
Yao et al., Immunity 1995 : Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappa B activity and interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation