Gene interactions and pathways from curated databases and text-mining

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KRT15 — NFKB1

Text-mined interactions from Literome

Brinkmann et al., J Virol 2007 : K15 interacts with cellular proteins, TRAF ( tumor necrosis factor receptor associated factor ) and Src kinases, and activates AP-1, NF-kappaB , and the mitogen activated protein kinases ( MAPKs ) c-jun-N-terminal kinase and extracellular signal regulated kinase
Wang et al., J Gen Virol 2007 (MAP Kinase Signaling System) : Similarly to K15-P, K15-M induces the activation of the Erk2 and JNK1 kinases, the NF-kappaB transcription factor and the expression of a similar range of cellular inflammatory genes, as assessed by gene-expression microarray studies and reporter assays
Tsai et al., J Virol 2009 : K15M localizes to lysosomal membranes and induces cell migration, invasion, and NF-kappaB ( but not AP-1 ) activity via its conserved SH2 binding motif