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SPP1 — UTP15
Text-mined interactions from Literome
Chaulet et al., Circ Res 2001
:
In parallel,
UTP increased
osteopontin expression dose-dependently ... Moreover, the blockade of ERK-1/ERK-2 MAP kinase or rho protein pathways led to the inhibition of both
UTP induced
osteopontin increase and migration, demonstrating the central role of osteopontin in this process
Seye et al., Circulation 2002
(Carotid Stenosis...) :
ATP or
UTP also
stimulated osteopontin expression in cultured SMCs in a dose dependent manner ... Furthermore, P2Y2 antisense oligonucleotide inhibited
osteopontin expression
induced by
UTP
Renault et al., Arch Mal Coeur Vaiss 2003
:
[ Mechanisms of regulation of
osteopontin expression
mediated by
UTP , angiotensin II and PDGF in arterial smooth muscle cells ]
Renault et al., Circ Res 2003
:
AP-1 is involved in
UTP induced
osteopontin expression in arterial smooth muscle cells ... Moreover, we recently demonstrated that the extracellular nucleotide
UTP also
induces OPN expression and that OPN is essential for UTP mediated SMC migration ... First, we explored the contribution of mRNA stabilization and transcription in the increase of
UTP induced
OPN mRNA levels ... Then, to identify transcription factors involved in
UTP induced
OPN transcription, we located a promoter element activated by UTP within the rat OPN promoter using a gene reporter assay strategy ... The -96 to +1 region mediated
UTP induced
OPN overexpression ( +276+/-60 % ) ... Thus, this AP-1 ( -76 ) site is involved in
UTP induced
OPN transcription
Renault et al., J Biol Chem 2005
:
UTP induces
osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells ... Using dominant negative mutants of IkappaB kinase and USF transcription factors, we confirmed that NFkappaB and USF-1/USF-2 are involved in the
UTP mediated expression of
OPN ... Finally, our work suggests that the
UTP stimulated
OPN expression involves a coordinate regulation of PKCdelta-NFkappaB, ERK1/2-USF, and ERK1/2/NAD ( P ) H oxidase AP-1 signaling pathways
Jalvy et al., Circ Res 2007
(MAP Kinase Signaling System) :
The present study aims to determine the role of CREB in
UTP induced migration and
OPN expression in cultured SMCs ... Both overexpression of a dominant negative CREB and CREB small interfering RNA treatment suppressed
UTP induced
OPN expression and SMC migration ... Mutations of these sites showed that only the 2 AP-1 sites were required for
UTP induced
OPN expression ... These results demonstrate that CREB participates in the induction of
UTP activated
OPN expression via its binding to 2 AP-1 sites and is thus involved in UTP mediated SMC migration