Gene interactions and pathways from curated databases and text-mining

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CXCL12 — EGF

Text-mined interactions from Literome

Azenshtein et al., Cancer Lett 2005 (Breast Neoplasms...) : EGF potently up-regulated CXCL8 secretion by breast tumor cells, and its effect was promoted by a consecutive treatment of the cells by estrogen and progesterone
Guo et al., Colloids Surf B Biointerfaces 2007 (Neoplasm Metastasis...) : In this research, the result first showed that epidermis growth factor (EGF) enhanced the expression of CXCR4 and the migration of ovarian cancer cells, moreover, both stromal cell derived factor-1alpha ( SDF-1alpha ) and EGF induced high matrix metallopeptidase 9 (MMP9) expressions
Sciaccaluga et al., Am J Physiol Cell Physiol 2010 (Brain Neoplasms...) : Furthermore, we demonstrate that both CXCL12 and EGF induce Ca ( 2+ ) mobilization and IK ( Ca ) channel activation but only CXCL12 induces a long-term upregulation of the IK ( Ca ) channel activity
Haim et al., Neoplasia (New York, N.Y.) 2011 (Breast Neoplasms) : We found that stimulation by EGF alone induced the release of CXCL8 through signaling pathways involving ErbB2, ErbB1, Erk, and phosphoinositide 3-kinase (PI3K)
Son et al., Journal of inflammation (London, England) 2013 : Finally, CCL20 and CXCL8 responded synergistically in response to EGF and TNF in OVCAR-3 and SKOV-3 cells