Gene interactions and pathways from curated databases and text-mining

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PRL — RELA

Text-mined interactions from Literome

Telleria et al., J Mol Endocrinol 2004 : Furthermore, NFkappaB DNA binding activity was enhanced by prolactin in luteinized granulosa cells
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : Our studies showed that 16-kDa PRL specifically blocked IRF-1 but not NF-kappaB signaling to the iNOS promoter
Um et al., J Biol Chem 2006 (Neuroblastoma) : In these cells Prl treatment strongly activates the STAT5, AKT, and MAPK signaling pathways and induces weak activation of the p65 NF-kappaB factor
Boutet et al., J Dairy Sci 2007 (Mastitis, Bovine) : Prolactin activated NF-kappaB ; maximal NF-kappaB activation was weaker with PRL than with TNF-alpha at 30 or 180 min poststimulation
Sodhi et al., Cytokine 2008 : It is further shown that p38 MAP kinase, STAT3 and NF-kappaB could play a differential regulatory role in PRL or GH induced production of cytokines by macrophages