Jacob et al., Endocrinology 1999
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Expression of C/EBP alpha increased basal PRL gene expression almost 6-fold, whereas expression of Chop10 that can act as an inhibitor of C/EBP alpha reduced the basal activity of the PRL promoter 60-75 %
Jacob et al., J Biol Chem 2001
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Expression of both C/EBPalpha and Pit-1 in CHO cells is required for high basal transcription of prolactin-CAT Jolivet et al., J Cell Biochem 2001
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This suggests that C/EBP binding activity was regulated by ECM and not by Prl Enwright et al., Mol Endocrinol 2003
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Here, we correlate cooperative activation of prolactin (PRL) gene transcription by Pit-1 and C/EBPalpha with changes in the subnuclear localization of these factors in living pituitary cells ... Transiently expressed C/EBPalpha induced PRL gene transcription in pituitary GHFT1-5 cells, whereas the coexpression of Pit-1 and C/EBPalpha in HeLa cells demonstrated their cooperativity at the PRL promoter