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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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NFKB1 — RHOB

Text-mined interactions from Literome

Fritz et al., J Biol Chem 2001 : Ras related GTPase Rhob represses NF-kappaB signaling ... However, RhoB inhibited both basal and genotoxic agent stimulated activity of the transcription factor nuclear factor kappaB (NF-kappaB) ... Thus, RhoB attenuated alkylation induced increase in the DNA binding activity of NF-kappaB and abrogated NF-kappaB-driven gene expression ... This indicates that RhoB represses NF-kappaB activation by inhibiting dissociation and subsequent degradation of IkappaBalpha
Rodriguez et al., Cell Signal 2007 : ROCK I-mediated activation of NF-kappaB by RhoB ... Here we show that RhoB can activate NF-kappaB signaling in multiple cell types ... Whereas RhoB-F is a potent activator of NF-kappaB , much weaker activation is observed for RhoB-GG, RhoA, and RhoC ... NF-kappaB activation by RhoB is not associated with increased nuclear translocation of RelA/p65, but rather, by modification of the RelA/p65 transactivation domain ... Activation of NF-kappaB by RhoB is dependent upon ROCK I but not PRK I ... Suppression of RhoB activity by dominant-inhibitory mutants, or siRNA, blocks NF-kappaB activation by Bcr, and TSG101, but not by TNFalpha or oncogenic Ras