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BRCA1 — MYLIP
Text-mined interactions from Literome
Moskwa et al., Mol Cell 2011
:
Antagonizing
miR-182 enhances
BRCA1 protein levels and protects them from IR-induced cell death, while overexpressing miR-182 reduces BRCA1 protein, impairs homologous recombination mediated repair, and render cells hypersensitive to IR ... Conversely, antagonizing
miR-182 enhances
BRCA1 levels and induces resistance to PARP1 inhibitor ... Together these results suggest that
miR-182 mediated downregulation of
BRCA1 impedes DNA repair and may impact breast cancer therapy
Chang et al., Nat Med 2011
:
Mechanistically, we found that
BRCA1 epigenetically
represses miR-155 expression via its association with HDAC2, which deacetylates histones H2A and H3 on the miR-155 promoter
Li et al., Toxicological sciences : an official journal of the Society of Toxicology 2012
(Carcinoma, Non-Small-Cell Lung...) :
In summary, we suggest that
miR-638 is
involved in the BaP induced carcinogenesis by targeting
BRCA1