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CXCL10 — STAT3
Text-mined interactions from Literome
Burger et al., Oncogene 2005
(Cell Transformation, Neoplastic...) :
In CXCR2 transfected NIH 3T3 cells and human microvascular endothelial cells ( HMEC ), which express the CXCR2 constitutively,
STAT3 is phosphorylated upon
stimulation with IL-8 (
CXCL8 )
Kanda et al., Endocrinology 2011
(Psoriasis) :
This indicates the involvement of NF-?B in CXCL8, CXCL10, and CCL20 induction by visfatin and the
involvement of
STAT3 in
CXCL8 induction
Lee et al., J Biol Chem 2011
(Inflammation) :
In particular,
up-regulation of
CXCL10 by
JAK2/STAT3 and IKK/NF-?B pathways in astrocytes played a pivotal role in LCN2 induced cell migration
Zeitvogel et al., J Biol Chem 2012
(Chronic Disease...) :
Lack of SOCS3 up-regulation in skin epithelial cells was accompanied by prolonged STAT1 and
STAT3 phosphorylation and
enhanced CXCL10 production upon IL-27 stimulation compared with macrophages
Pini et al., J Leukoc Biol 2012
(Inflammation...) :
However, the delayed resolution of neutrophil infiltration ; sustained production of CXCL1,
CXCL2 , and CCL2 ; prolonged
activation of
STAT-3 ; and induction of MMP-7 in the pancreas, as well as heightened induction of serum amylase A of DIO mice, were blunted significantly in DIO IL-6 KO mice
Liu et al., PloS one 2012
(Malaria) :
Then, we further determined the mechanisms how
STAT3 regulates HO-1 and
CXCL10 as well as mutual regulation among them in CRL-2581, a murine endothelial cell line