Allen et al., Mol Cell Biol 2002
:
Gas6/Ark signaling promoted activation of the Rho family GTPase Rac , and adenoviral mediated expression of dominant negative N17Rac abolished Gas6/Ark induced actin cytoskeletal reorganization and migration of GnRH neuronal cells
Nielsen-Preiss et al., Endocrinology 2007
:
In addition, PI3K inhibition in GnRH neuronal cells diminished Gas6 induced Rac activation
Grommes et al., J Neuroimmune Pharmacol 2008
(Inflammation) :
Gas6 stimulates a type-II related phagocytic response, but requires Vav phosphorylation and Rac activation, distinguishing it from the classical type II mechanism