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ICOS — IFNG

Text-mined interactions from Literome

Coyle et al., Immunity 2000 : We suggest that ICOS , the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell dependent B help in vivo
Ogasawara et al., J Immunol 2002 (Leukemia, Experimental) : Consistent with ICOS expression on activated NK cells, ICOS dependent cytotoxicity and IFN-gamma production were observed, and appeared to require signaling through the phosphoinositide 3-kinase pathway
Stanciu et al., J Infect Dis 2006 (Respiratory Syncytial Virus Infections) : We used flow-cytometric analysis to investigate programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulatory ligand (ICOS-L) expression on tracheal ( NCI-H292 ), bronchial ( BEAS-2B ), and alveolar ( A549 ) epithelial cells ; regulation of this expression by RSV, interferon (IFN)- gamma , and interleukin (IL)-4 ; and the effects of IFN-gamma and IL-4 on RSV induced expression of these molecules
Montufar-Solis et al., Biochem Biophys Res Commun 2006 (Reoviridae Infections) : In vitro ICOS stimulation by syngeneic peritoneal macrophages induced IFN-gamma secretion from IELs from day 7 infected mice, and was suppressed by treatment with anti-ICOS mAb ... These findings indicate that S7- and S7+ IELs are differentially mobilized during the immune response to reovirus infection ; that the regulated expression of ICOS is associated with S7+ IELs ; and that stimulation of IELs through ICOS enhances IFN-gamma synthesis during infection
Quiroga et al., J Immunol 2006 (Tuberculosis, Pulmonary) : Besides, in human polarized Th cells, engagement of ICOS increased M. tuberculosis IFN-gamma production with a magnitude proportional to ICOS levels on those cells ... Moreover, ICOS ligation augmented Ag-specific secretion of the Th1 cytokine IFN-gamma from responsive individuals ... In contrast, neither Th1 nor Th2 cytokines dramatically affected ICOS levels on Ag-stimulated T cells from LR patients, and ICOS activation did not enhance IFN-gamma production ... However, simultaneous activation of ICOS and CD3 slightly augmented IFN-gamma secretion by LR patients
Mesturini et al., Eur J Immunol 2006 : ICOS strikingly potentiated secretion of IL-2, IFN-gamma , IL-10, and TNF-alpha, but not IL-4, promoted by optimal stimulation of CD3+CD28, and it was the key switching-factor of activation when cells received suboptimal stimulation of CD3+CD28 or stimulation of CD3 alone in the presence of exogenous IL-2
Waeckerle-Men et al., Kidney Blood Press Res 2007 : Stimulation of TEC with IFN-beta or IFN-gamma , but not other tested cytokines, enhanced the expression of PD-L1, ICOS-L and CD40
Schenk et al., Am J Transplant 2009 : ICOS blockade significantly reduced IFN-gamma production and other proinflammatory functions of the activated CD8 memory T cells
Nagamatsu et al., Immunol Cell Biol 2011 : ICOS ligation enhanced T-cell secretion of interferon-gamma ( IFN-? ) and interleukin-10 (IL-10), but not IL-2