Li et al., Zhonghua Xue Ye Xue Za Zhi 2005
(MAP Kinase Signaling System) :
Phosphorylation of MEK1 in UT7 cells can be induced by TPO Ezumi et al., Eur J Biochem 1998
:
TPO did not activate the mitogen activated protein kinase/ERK kinases, MEK1 and MEK2, but activated Raf-1 and directly augmented the PKC mediated MEK activation, suggesting that TPO primarily potentiates the ERK pathway through regulating MEKs or upstream steps of MEKs including Raf-1