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IRF6 — MUC5AC
Text-mined interactions from Literome
Zen et al., Am J Pathol 2002
(Liver Diseases) :
It was found that
LPS up-regulated the expression of MUC2 and
MUC5AC in cultured murine biliary epithelial cells ... These findings suggest that
LPS can
induce overexpression of MUC2 and
MUC5AC in biliary epithelial cells via synthesis of TNF-alpha and activation of protein kinase C
Slomiany et al., IUBMB Life 2003
(Helicobacter Infections) :
In this study, we report that PPARgamma activation leading to the impedance of H. pylori
lipopolysaccharide (LPS) inhibitory
effect on
gastric mucin synthesis occurs with the involvement of phosphatidylinositol 3-kinase (PI3K) and extracellular signal regulated kinase ( ERK ) pathways
Shao et al., Proc Natl Acad Sci U S A 2003
:
PMA, PA sup, and
LPS increased
MUC5AC gene expression and mucin protein production, effects that were prevented by pretreatment with AG1478, a selective inhibitor of EGFR phosphorylation and by preincubation with an EGFR neutralizing Ab or with a TGF-alpha neutralizing Ab, implicating ligand ( TGF-alpha ) -dependent EGFR phosphorylation in mucin production
Slomiany et al., Inflammopharmacology 2004
:
These findings indicate that PPARgamma activation leading to the suppression of H. pylori
LPS inhibition of
gastric mucin synthesis involves Src kinase dependent EGFR transactivation
Gray et al., Mol Pharmacol 2004
:
We also observed that tumor necrosis factor (TNF)-alpha, platelet activating factor (PAF), and
lipopolysaccharide (LPS) induced COX-2 and increased
MUC5AC production that was blocked by celecoxib, suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells ... We conclude that the
induction of
MUC5AC by IL-1beta, TNF-alpha, PAF, and
LPS involves COX-2- generated PGE ( 2 ), activation of EP2 and/or EP4 receptor ( s ), and cAMP-PKA mediated signaling
He et al., Acta Pharmacol Sin 2004
:
LPS can
induce MUC5AC mucin release from HSBTF and HBEC
Slomiany et al., Scand J Gastroenterol 2005
:
The
LPS inhibitory
effect on
gastric mucin synthesis was accompanied by a marked increase in ET-1 generation and enhancement in ECE-1 activity
Griffin et al., Cell Microbiol 2007
:
In particular,
MUC5AC expression can be
induced by cigarette-smoke, neutrophil elastase and
lipopolysaccharide (LPS) following activation of tumour necrosis factor alpha converting enzyme
Rhee et al., Eur Respir J 2008
:
MUC5AC mucin synthesis and the expression of the
MUC5AC gene were
increased by
LPS in rats or TNF-alpha in NCI-H292 cells ; these effects were inhibited by fudosteine treatment
Antonela Antoniu et al., Expert Opin Investig Drugs 2009
:
Both
LPS and TNF-alpha
increased MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene
Wang et al., Arch Biochem Biophys 2009
:
We explored the role of MMP-9 in
LPS induced MUC5AC production and the effect of doxycycline on
MUC5AC production ... The study showed that
LPS induced transcription and protein expression of both MMP-9 and
MUC5AC in NCI-H292 cells and in primary human epithelial cells, and the increased MUC5AC level were associated with increased MMP-9 transcripts, protein and activity ... These results suggested that
LPS induced
MUC5AC production may be partially mediated by MMP-9 activation and EGFR-p38 MAPK/JNK signaling pathway
Binker et al., Biochem Biophys Res Commun 2009
(Pulmonary Disease, Chronic Obstructive) :
LPS stimulated
MUC5AC production involves Rac1 dependent MMP-9 secretion and activation in NCI-H292 cells ... Previous studies have reported that
lipopolysaccharides (LPS) stimulate
mucin 5AC (MUC5AC) production via epidermal growth factor receptor (EGFR) in human airway cells
Gosalia et al., J Biol Chem 2013
:
LPS increased the expression of MUC2 and
MUC5AC and reduced MUC5B
Yang et al., Ann Hepatol 2013
(Cholelithiasis) :
Selective COX-2 inhibitor suppressed
LPS induced MUC2 and
MUC5AC mRNA expression remarkably
Li et al., PloS one 2013
:
Our aim was to clarify whether Duox1 was also involved in the
PA-LPS induced
MUC5AC and calcium dependent chloride channel 3(Clca3), another recognized marker of goblet cell hyperplasia and mucus hyper production ... Nox inhibitors diphenyleneiodonium chloride ( DPI ) and Duox1 siRNA were used to investigate whether Duox1 is involved in
PA-LPS induced
MUC5AC and Clca3 expression both in vitro and in vivo ... DPI significantly inhibited
PA-LPS induced up-regulation of Duox1,
Muc5ac and Clca3 in primary mouse trachea epithelial cells and lung tissues of mice ... Knockdown of Duox1 markedly inhibited
PA-LPS induced
MUC5AC expression via a ROS-TGF-a cascade in A549 cells ... We demonstrate for the first time that
PA-LPS induced
MUC5AC and Clca3 expression is partly through Duox1, and provide supportive evidence for Duox1 as a potential target in treatments of mucin over production diseases