UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NOTCH1

NOTCH1 — RBBP8

Pathways - manually collected, often from reviews:

NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch-mediated HES/HEY network: CtIP/CtBP/LSD1 complex (RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch-mediated HES/HEY network: CtIP/CtBP/LSD1 complex (RBBP8-CTBP1-KDM1A) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (transcription, inhibits)
Maier et al., Biochem Biophys Res Commun 2000, Iso et al., Mol Cell Biol 2001, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database Notch signaling pathway: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch signaling pathway: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch signaling pathway: CtIP/CtBP/LSD1 complex (RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Notch signaling pathway: CtIP/CtBP/LSD1 complex (RBBP8-CTBP1-KDM1A) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
Evidence: mutant phenotype, physical interaction