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LEP — UCP3

Text-mined interactions from Literome

Gómez-Ambrosi et al., Cell Mol Life Sci 1999 (Obesity) : Leptin , but not a beta 3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression : short-term thermogenic interactions ... The present study provides evidence, for the first time, of the induction of UCP3 mRNA expression in skeletal muscle by leptin in nongenetically obese animals
Giacobino et al., Int J Obes Relat Metab Disord 1999 (Obesity) : The effects of PPARgamma agonists and leptin on BAT and muscle UCP3 mRNA expression are also discussed
Cusin et al., Diabetes 2000 (Hypothyroidism) : To further substantiate an involvement of thyroid hormones in the effect of leptin on muscle UCP-3 expression, hypothyroid rats were ICV infused with leptin or vehicle ... These results suggest that central leptin stimulates T3 production via an activation of T4 to T3 conversion, and that this stimulation could be responsible for the effect of leptin on muscle UCP-3 expression
Villarroya et al., Biochem Soc Trans 2001 : The speed of the effects of leptin on UCP3 mRNA expression suggests a direct action on skeletal muscle and BAT
Giacobino et al., Ann N Y Acad Sci 2002 (Obesity) : Besides its well-known effect on brown adipose tissue UCP1, leptin might stimulate indirectly muscle UCP3 expression
Ramsay et al., Domest Anim Endocrinol 2005 : Expression of UCP3 was inhibited by growth hormone ( 100 ng/mL ; P < 0.05 ), tri-iodothyronine ( 10 nM ; P < 0.05 ) or leptin ( 100 ng/mL ; P < 0.05 )
Luo et al., Mol Cell Biochem 2008 : Furthermore, at the level of 10 and 100 ng/ml leptin not only selectively increased the gene expression of PGC-1alpha, CPT1, Cyt c, UCP2, and UCP3 ( P < 0.05 ), but also enhanced COX enzyme activity which related to mitochondrial FAO
Gong et al., J Biol Chem 1997 (Starvation) : UCP3 mRNA levels were also regulated by dexamethasone, leptin , and starvation, albeit differently in muscle and brown adipose tissue
Liu et al., Gene 1998 : Furthermore, adenovirus mediated leptin expression in obese ob/ob mice led to increased expression of UCP3 in skeletal muscle
Scarpace et al., J Endocrinol 1998 : Leptin increased LPL mRNA by 80 %, UCP1 mRNA twofold, and UCP3 mRNA levels by 62 % in BAT, and increased UCP2 mRNA levels twofold in EWAT