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HDAC2 — RELA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Kiernan et al., J Biol Chem 2003*
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IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Ito et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Yu et al., J Am Soc Nephrol 2002*
-
IRef Biogrid Interaction:
HDAC2
—
RELA
(direct interaction, pull down)
Yu et al., J Am Soc Nephrol 2002*
-
IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Ito et al., Mol Cell Biol 2000
-
IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Wang et al., FASEB J 2010*
-
IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Sun et al., J Biol Chem 2007
-
IRef Biogrid Interaction:
HDAC2
—
RELA
(physical association, affinity chromatography technology)
Adenuga et al., Arch Biochem Biophys 2010*
-
IRef Hprd Interaction:
HDAC2
—
RELA
(in vitro)
Yu et al., J Am Soc Nephrol 2002*, Kiernan et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
HDAC2
—
RELA
(in vivo)
Yu et al., J Am Soc Nephrol 2002*, Kiernan et al., J Biol Chem 2003*
-
MIPS Negatome - no physical interaction between proteins Interaction:
HDAC2
—
RELA
(Absence of interaction, coimmunoprecipitation)
Ashburner et al., Mol Cell Biol 2001*
-
IRef Ophid Interaction:
HDAC2
—
RELA
(aggregation, confirmational text mining)
Kiernan et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
HDAC2
—
RELA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Xiao et al., J Biol Chem 2000
:
Consistently, when expressed alone, the
NRD potently
inhibits NIK mediated
NF-kappaB signaling
Ashburner et al., Mol Cell Biol 2001
:
HDAC2 does not interact with NF-kappaB directly but can
regulate NF-kappaB activity through its association with HDAC1
Rahman et al., Biochem Pharmacol 2002
(Pneumonia) :
Pharmacological inhibition of
HDAC leads to the increased HAT activity, AP-1 and
NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments
Mayo et al., J Biol Chem 2003
(Carcinoma, Non-Small-Cell Lung...) :
Because the anti-apoptotic transcription factor NF-kappa B has been shown to be under the control of HDAC mediated repression, we analyzed whether
HDAC inhibitors
activated NF-kappa B in NSCLC cells ...
HDAC inhibitors effectively
stimulated endogenous
NF-kappa B-dependent gene expression by up-regulating IL-8, Bcl-XL, and MMP-9 transcripts
Foss et al., Leukemia & lymphoma 2003
(Lymphoma, T-Cell, Cutaneous) :
Other novel agents include the interleukin (IL)-2 fusion toxin ( ONTAK ), pentostatin ( a potent adenosine deaminase inhibitor ),
histone deacetylase inhibitors such as depsipeptide,
NF-kappaB inhibitors , cytokine receptor antagonists, immunomodulatory therapies and allogeneic stem cell therapy
Singh et al., Oncogene 2005
(Breast Neoplasms) :
HDAC inhibitors
synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through
NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Place et al., Biochem Pharmacol 2005
:
HDAC inhibition
prevents NF-kappa B activation by suppressing proteasome activity : down-regulation of proteasome subunit expression stabilizes I kappa B alpha
Shetty et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Indeed,
HDAC inhibitors
activate NF-kappaB and p53 and upregulate DR5 expression
Graham et al., Cell cycle (Georgetown, Tex.) 2005
:
In addition,
HDAC inhibitors
induce NFkappaB binding to the DR5 gene and DR5 expression, contributing to HDAC inhibitor induced apoptosis
Ito et al., J Exp Med 2006
(Pulmonary Disease, Chronic Obstructive) :
Loss of
HDAC2 did not reduce GR nuclear translocation, GR binding to glucocorticoid response element ( GRE ) on DNA, or GR-induced DNA or gene induction but
inhibited the association between GR and
NF-kappaB
Kammanadiminti et al., J Biol Chem 2006
(Colitis) :
Overexpression of wild type Hsp27 amplified the effects of SAP, whereas a phosphorylation-deficient mutant of Hsp27 abrogated
SAP induced
NF-kappaB inhibition
Kim et al., Biochem Biophys Res Commun 2006
:
Involvement of HDAC1 and the PI3K/PKC signaling pathways in
NF-kappaB activation by the
HDAC inhibitor apicidin ... Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not
HDAC2 , 3 or 4, dramatically
inhibits NF-kappaB reporter gene activity
Andresen et al., J Immunol 2007
:
NF-kappaB activity can be
induced by
HDAC treatment
Glauben et al., Gut 2008
(Colitis...) :
As for potential mechanisms of ITF2357 action, increased acetylation of histone 3, reduced production of IFN gamma and enhanced apoptosis in lamina propria mononuclear cells were found to accompany a
histone deacetylase dependent
activation of
NF-kappaB
Kaler et al., Exp Cell Res 2008
(Colonic Neoplasms) :
We showed that overexpression of
HDAC2 enhanced TNFalpha induced
NF-kappaB activity and that silencing of HDAC2 decreased NF-kappaB activity
Hayes et al., Eur J Nutr 2008
(Neoplasms) :
In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 ( NF-E2 related factor 2 ) and AhR ( arylhydrocarbon receptor ) transcription factors, and their abilities to repress
NF-kappaB ( nuclear factor-kappaB ) activity,
inhibit histone deacetylase , and inhibit cytochrome P450 are outlined
Chavey et al., Mol Pharmacol 2008
(Breast Neoplasms) :
In summary, our results demonstrate that
NF-kappaB pathway
repression by
HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells
Farhana et al., Mol Cancer Ther 2009
:
We examined the
effect of loss of SHP and
Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated
nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression
Zhang et al., Am J Physiol Heart Circ Physiol 2010
(Disease Models, Animal...) :
Luciferase assay demonstrated an
activation of
NF-kappaB by
HDAC inhibition