Gene interactions and pathways from curated databases and text-mining

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APOB — APOC3

Pathways - manually collected, often from reviews:

  • Reactome Reaction: APOB → APOC3 (reaction)
  • Reactome Reaction: APOB → APOC3 (indirect_complex)

Text-mined interactions from Literome

Black et al., Biochem J 1992 : Apo B may be specifically down-regulated by the chylomicron secretory blockade induced by Pluronic L-81
Huard et al., Int J Biochem Cell Biol 2005 (Carcinoma, Hepatocellular) : Different levels of secreted apoC-II or apoC-III had little effect on LDL and HDL protein degradation by HepG2 cells
Furtado et al., J Lipid Res 2012 (Hypercholesterolemia) : ApoC-III inhibits VLDL and LDL clearance, and it stimulates inflammatory responses in vascular cells
Levy et al., FEBS Lett 1996 : Adding insulin ( 3 mU ) to the serum-free medium of cultured jejunal explants from human fetuses ( 17-20 weeks ) reduced triglyceride and chylomicron production and inhibited apo B-48 and apo B-100 secretion
Taggart et al., Diabet Med 1997 (Diabetes Mellitus, Type 2) : The postprandial chylomicron apolipoprotein B48 response of both diabetic and control subjects to the cholesterol meal was less than to the cholesterol-free meal ( p < 0.001 )