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CD4 — ITGB1

Text-mined interactions from Literome

Gendron et al., Immunology 2008 : Furthermore, we found that simultaneous activation of effector CD4 ( + ) T cells via alpha1beta1 integrin and IL-7R synergistically increases the production of RANKL and enhances their osteoclastogenic function ... Together our results identify a new function of alpha1beta1 integrin in T cells and suggest that activation of effector CD4 ( + ) T cells through alpha1beta1 integrin and IL-7R is an important regulatory pathway in T-cell dependent osteoclastogenesis
Nojima et al., J Exp Med 1990 : VLA-4 mediates CD3 dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin ... In the present study, we showed that VLA-4 is also involved in this CD3 dependent CD4 cell activation through its interaction with the alternatively spliced CS1 domain of FN ... These results strongly suggest that CD4 cell activation induced by plasma FN/anti-CD3 may be dependent on both VLA4/CS1 and VLA5/RGDS interactions, although the latter interaction may be required for function of the former