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EPO — SHC1

Pathways - manually collected, often from reviews:

• BioCarta epo signaling pathway: EPO/EPO R/EPO R complex (EPOR-EPO) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  

Text-mined interactions from Literome

Lecoq-Lafon et al., Blood 1999 (Leukemia) : Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC , SHP2, SHIP, and phosphatidylinositol 3-kinase
Mason et al., J Biol Chem 2000 : Erythropoietin (EPO) , the primary regulator of erythropoiesis, has been shown to activate the tyrosine phosphorylation of Shc , resulting in recruitment of Grb2
Liu et al., Mol Cell Biol 1994 : We recently reported that interleukin-3, Steel factor, and erythropoietin all induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cell lines
He et al., J Biol Chem 1995 : FDC-P1 cells stably expressing the wild type murine EPOR supported the EPO induced association of Shc with Jak2 and its rapid tyrosine phosphorylation ... Together, these studies indicate that Jak2, in part, may mediate the EPO induced phosphorylation of Shc
Damen et al., Blood 1993 : Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
Chin et al., Biochem Biophys Res Commun 1997 : Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc , SHP-2, and Cbl in hematopoietic cells ... The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3 containing adapter protein CrkL and its transient association with tyrosine phosphorylated SHP-2, Shc , and Cbl in a murine IL-3 dependent cell line, 32D, expressing the Epo receptor (EpoR)