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CTNNB1 — PPARD
Pathways - manually collected, often from reviews:
-
BioCarta wnt signaling pathway:
beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4)
→
PPAR-delta (PPARD)
(transcription, activates)
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 complex (CTNNB1-HNF1A-CTBP1-CREBBP-TLE1-AES)
→
PPAR delta (PPARD)
(transcription, activates)
Text-mined interactions from Literome
Reed et al., Oncogene 2004
(Intestinal Neoplasms...) :
Our data suggest that
PPARdelta is not directly
regulated by
beta-catenin , and that inhibition of PPARdelta activity is unlikely to be an appropriate strategy for the chemoprevention or chemotherapy of intestinal malignancies
Han et al., J Cell Biochem 2008
(Cholangiocarcinoma) :
Overexpression of
PPARdelta or treatment with the selective PPARdelta ligand, GW501516, also
increased beta-catenin binding to TCF/LEF response element and increased its reporter activity
Jeong et al., Cell cycle (Georgetown, Tex.) 2009
:
In addition,
PPARdelta increased protein kinase C ( PKC ), cytosolic phospholipase A ( 2 ) ( cPLA(2) ) and p38 mitogen activated protein kinase ( p38 MAPK ) phosphorylation, and
Wnt/beta-catenin activation