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EIF2AK2 — IGF1

Text-mined interactions from Literome

Chacko et al., Endocrinology 2002 (Brain Neoplasms...) : Poly ( IC ) activated double stranded RNA activated protein kinase ( PKR ) at 5 min and increased PKR protein levels at 48 and 72 h. Exogenous IGF-I did not prevent Poly ( IC ) from activating PKR , but inhibited the Poly ( IC ) -mediated increase in PKR protein levels
Chacko et al., Endocrinology 2002 (Brain Neoplasms...) : Both IGF-I and a blocking antibody against type I interferon ( IFN ) prevented the increase in PKR levels and the decrease in cell proliferation caused by poly ( IC ) ... IGF-I prevents IFN from inducing PKR , thus explaining the ability of IGF-I to reverse the cell cycle blocks and the decreased C6 proliferation caused by poly ( IC )
Russell et al., Cell Signal 2007 : Angiotensin II induced phosphorylation of PKR and of the eukaryotic initiation factor-2 ( eIF2 ) on the alpha-subunit, and this was attenuated by IGF-I , by induction of the expression of protein phosphatase 1, which dephosphorylates PKR