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KRAS — LGALS3

Text-mined interactions from Literome

Elad-Sfadia et al., J Biol Chem 2004 : Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity
Plowman et al., Mol Cell Biol 2008 (MAP Kinase Signaling System) : Phosphorylation of S181 does not, however, regulate in vivo interactions with the nanocluster scaffold galectin-3 (Gal3), indicating separate roles for the polybasic domain and Gal3 in driving K-Ras nanocluster formation
Shalom-Feuerstein et al., Cancer Res 2008 (Breast Neoplasms) : Thus, regulation of K-Ras nanocluster formation and signal output by Gal-3 critically depends on the integrity of the Gal-3 hydrophobic pocket
Levy et al., PloS one 2011 : To gain a better understanding of what regulates the critical interactions between these two proteins, we examined the role of Gal-3 in the regulation of K-Ras by using Gal-3-knockout mouse embryonic-fibroblasts ( Gal-3-/- MEFs ) and/or Gal-3/Gal-1 double-knockout MEFs