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CD40 — CHUK

Pathways - manually collected, often from reviews:

• WikiPathways NLR Proteins: IKBKG/CHUK/IKBKB → Complex of RELA-CD40 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: CHUK — CD40 (interaction, mapped from grid)
• STRING interaction: CD40 — CHUK (interaction, mapped from grid)

Text-mined interactions from Literome

Kosaka et al., Eur J Immunol 1999 : Activation and regulation of the IkappaB kinase in human B cells by CD40 signaling
Manning et al., Eur J Immunol 2002 : Engagement of CD40 by its ligand induces IKK and mitogen activated protein kinase ( MAPK ) phosphorylation and transcriptional activation, leading to activation and differentiation of B cells
Ho et al., Blood 2005 (Lymphoma, B-Cell...) : API2-MALT1 and exogenous MALT1 increased constitutive NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation
Mukundan et al., J Immunol 2005 : However, ligation of a CD40 mutant lacking a functional TRAF6 binding site did not initiate inflammatory cytokine production, and this mutant was found to be defective in CD40 mediated activation of ERK1/2, as well as IkappaB kinase (IKK) and NF-kappaB ... Finally, treatment of monocytes with a cell-permeable peptide corresponding to the TRAF6 binding motif of CD40 inhibited CD40 activation of ERK1/2, IKK , and inflammatory cytokine production
Chan et al., Biochem Biophys Res Commun 2005 : Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress CD40 mediated IkappaB kinase activation and induction of NFkappaB-responsive promoters, without affecting signaling by TNF
Taguchi et al., Genes Cells 2009 : TRAF6 is essential for osteoclastogenesis and for both RANK- and CD40 mediated activation of IKK and MAPKs