◀ Back to CTNNB1
CTNNB1 — LEF1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
LEF1
→
CTNNB1
(increases, CTNNB1 Activity, LEF1 Activity)
Sakamoto et al., J Biol Chem 2000*
Evidence: In response to Wnt, beta-catenin is stabilized and translocated into the nucleus where it stimulates gene expression through Tcf/Lef.
-
BioCarta multi-step regulation of transcription by pitx2:
beta-catenin (CTNNB1)
→
HDAC/LEF1 complex (HDAC1-LEF1)
(modification, activates)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
LEF1
→
beta-catenin (CTNNB1)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
LEF1
→
beta-catenin/LEF1 complex (CTNNB1-LEF1)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
beta-catenin (CTNNB1)
→
beta-catenin/LEF1 complex (CTNNB1-LEF1)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
beta-catenin/LEF1 complex (CTNNB1-LEF1)
→
CONNEXIN 43 (GJA1)
(transcription, activates)
-
KEGG Wnt signaling pathway:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Adherens junction:
LEF1/TCF7/TCF7L1/TCF7L2
→
CTNNB1
(protein-protein, binding/association)
-
KEGG Melanogenesis:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Pathways in cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Colorectal cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Colorectal cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Endometrial cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Prostate cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Thyroid cancer:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Basal cell carcinoma:
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
KEGG Arrhythmogenic right ventricular cardiomyopathy (ARVC):
CTNNB1
→
LEF1/TCF7/TCF7L1/TCF7L2
(protein-protein, activation)
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
HDAC1/LEF1 complex (HDAC1-LEF1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
HDAC1 (HDAC1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
HDAC1/LEF1 complex (HDAC1-LEF1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
CDX1 (CDX1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Béland et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
CDX1 (CDX1)
→
LEF1/beta catenin/CDX1 complex (LEF1-CTNNB1-CDX1)
(modification, collaborate)
Béland et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin complex (LEF1-CTNNB1)
→
LEF1/beta catenin/CDX1 complex (LEF1-CTNNB1-CDX1)
(modification, collaborate)
Béland et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin/PITX2 complex (LEF1-CTNNB1-PITX2)
→
LEF1 (LEF1)
(transcription, activates)
Vadlamudi et al., J Cell Sci 2005*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin/PITX2 complex (LEF1-CTNNB1-PITX2)
→
PITX2 (PITX2)
(modification, collaborate)
Vadlamudi et al., J Cell Sci 2005*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin/PITX2 complex (LEF1-CTNNB1-PITX2)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Vadlamudi et al., J Cell Sci 2005*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
PITX2 (PITX2)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Vadlamudi et al., J Cell Sci 2005*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin complex (LEF1-CTNNB1)
→
SLUG (SNAI2)
(transcription, activates)
Lambertini et al., BMC molecular biology 2010*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TLE2/LEF1 complex (TLE2-LEF1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE2 (TLE2)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE2/LEF1 complex (TLE2-LEF1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin complex (LEF1-CTNNB1)
→
E-cadherin (CDH1)
(transcription, inhibits)
Jamora et al., Nature 2003*
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
AES/LEF1 complex (AES-LEF1)
(modification, collaborate)
Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
AES (AES)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
AES/LEF1 complex (AES-LEF1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TLE1/LEF1 complex (TLE1-LEF1)
(modification, collaborate)
Wang et al., Curr Biol 2006*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Wang et al., Curr Biol 2006*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE1 (TLE1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Wang et al., Curr Biol 2006*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE1/LEF1 complex (TLE1-LEF1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Wang et al., Curr Biol 2006*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TLE1/LEF1 complex (TLE1-LEF1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*, Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Levanon et al., Proc Natl Acad Sci U S A 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*, Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Levanon et al., Proc Natl Acad Sci U S A 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE1 (TLE1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*, Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Levanon et al., Proc Natl Acad Sci U S A 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TLE1/LEF1 complex (TLE1-LEF1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*, Brantjes et al., Nucleic Acids Res 2001, Daniels et al., Nature structural & molecular biology 2005, Levanon et al., Proc Natl Acad Sci U S A 1998
Evidence: assay, physical interaction
-
Reactome Reaction:
LEF1
→
CTNNB1
(direct_complex)
Kramps et al., Cell 2002, Thompson et al., Nat Cell Biol 2002, Belenkaya et al., Development 2002, Ishitani et al., Mol Cell Biol 2003*, Hoffmans et al., Development 2004, Hoffmans et al., Curr Biol 2005, Städeli et al., Mech Dev 2005, Sierra et al., Genes Dev 2006, Shilatifard et al., Annu Rev Biochem 2006, Sampietro et al., Mol Cell 2006, Schwab et al., BMC biology 2007, Song et al., Development 2007, Li et al., Genesis 2007, Sustmann et al., Mol Cell Biol 2008, Jessen et al., Bioessays 2008, Fiedler et al., Mol Cell 2008, Gu et al., J Cell Biol 2009, Kessler et al., Mech Dev 2009, Gu et al., Cell cycle (Georgetown, Tex.) 2012, Valenta et al., Genes Dev 2011, Valenta et al., EMBO J 2012, Willis et al., Blood 1998
-
Reactome Reaction:
LEF1
→
CTNNB1
(reaction)
Omer et al., Biochem Biophys Res Commun 1999, Chen et al., Genes Dev 1999, Chen et al., Gene 2000, Graham et al., Cell 2000, Poy et al., Nat Struct Biol 2001, Brantjes et al., Biol Chem 2002, Song et al., Mol Cell Biol 2004, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009, Molenaar et al., Cell 1996, Behrens et al., Nature 1996, Pinto et al., J Biol Chem 1996, van de Wetering et al., Cell 1997, Korinek et al., Mol Cell Biol 1998, Levanon et al., Proc Natl Acad Sci U S A 1998, Chen et al., Mol Cell Biol 1998
-
WikiPathways TGF-beta Receptor Signaling:
CTNNB1
→
LEF1
(activation)
-
WikiPathways Wnt Signaling Pathway and Pluripotency:
CTNNB1
→
Complex of TCF7L2-LEF1-TCF7L1-TCF7
(activation)
-
WikiPathways Arrhythmogenic Right Ventricular Cardiomyopathy:
CTNNB1
→
LEF1/TCF7/TCF7L2/TCF7L1
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
TCF7/TCF7L1/TCF7L2/LEF1
→
CTNNB1
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
LEF1
—
CTNNB1
Hamada et al., Dev Cell 2004
-
IRef Bind_translation Interaction:
LEF1
—
CTNNB1
(coimmunoprecipitation)
Hamada et al., Dev Cell 2004
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Sadot et al., J Cell Sci 2002*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(direct interaction, two hybrid)
Behrens et al., Nature 1996
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(direct interaction, pull down)
Labbé et al., Proc Natl Acad Sci U S A 2000*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(direct interaction, pull down)
Sierra et al., Genes Dev 2006
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(direct interaction, pull down)
Gomes et al., Genes Dev 2006
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Vietor et al., J Biol Chem 2005*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Billin et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Fischer et al., J Cell Biochem 2002*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(colocalization, imaging technique)
Tutter et al., Genes Dev 2001
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Feigin et al., Cell Signal 2008*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Porfiri et al., Oncogene 1997*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(direct interaction, pull down)
Daniels et al., Nature structural & molecular biology 2005
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Hamada et al., Dev Cell 2004
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(direct interaction, pull down)
Vadlamudi et al., J Cell Sci 2005*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Grueneberg et al., Mol Cell Biol 2003*
-
IRef Biogrid Interaction:
CTNNB1
—
LEF1
(physical association, affinity chromatography technology)
Edlund et al., Mol Cell Biol 2005*
-
IRef Dip Interaction:
LEF1
—
CTNNB1
(direct interaction, pull down)
Weiske et al., Proc Natl Acad Sci U S A 2007*
-
IRef Dip Interaction:
Complex of CTNNB1-LEF1-FHIT
(pull down)
Weiske et al., Proc Natl Acad Sci U S A 2007*
-
Gene Ontology Complexes transcription factor complex:
transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3)
Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
-
IRef Hprd Interaction:
CTNNB1
—
LEF1
(in vivo)
Ishitani et al., Mol Cell Biol 2003*, Edlund et al., Mol Cell Biol 2005*, Behrens et al., Nature 1996
-
IRef Hprd Interaction:
CTNNB1
—
LEF1
(in vitro)
Ishitani et al., Mol Cell Biol 2003*, Edlund et al., Mol Cell Biol 2005*, Behrens et al., Nature 1996
-
IRef Hprd Interaction:
Complex of SMAD7-CTNNB1-LEF1-CTNNB1-SMAD7-LEF1-CTNNB1-SMAD7-LEF1
(in vivo)
Edlund et al., Mol Cell Biol 2005*
-
IRef Innatedb Interaction:
LEF1
—
CTNNB1
(unknown, -)
Vadlamudi et al., J Cell Sci 2005*
-
IRef Innatedb Interaction:
LEF1
—
CTNNB1
(unknown, -)
Porfiri et al., Oncogene 1997*
-
IRef Innatedb Interaction:
LEF1
—
CTNNB1
(unknown, -)
Edlund et al., Mol Cell Biol 2005*
-
IRef Innatedb Interaction:
LEF1
—
CTNNB1
(unknown, -)
Sadot et al., J Cell Sci 2002*
-
IRef Intact Interaction:
LEF1
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Humtsoe et al., Mol Cell Biol 2010*
-
IRef Intact Interaction:
LEF1
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Lu et al., Oncogene 2012*
-
IRef Intact Interaction:
Complex of CTNNB1-GSK3B-LEF1-EGR1-TCF4
(association, anti bait coimmunoprecipitation)
Lu et al., Oncogene 2012*
-
IRef Intact Interaction:
Complex of TCF4-CTNNB1-LEF1
(association, anti bait coimmunoprecipitation)
Lu et al., Oncogene 2012*
-
IRef Intact Interaction:
Complex of TCF4-CTNNB1-LEF1-CTNNB1-EGR1-EGR1-TCF4-LEF1
(association, anti bait coimmunoprecipitation)
Lu et al., Oncogene 2012*
-
IRef Intact Interaction:
Complex of LEF1-CTNNB1-CTNNB1-LEF1-IGF1R-IGF1R
(association, anti bait coimmunoprecipitation)
Warsito et al., EMBO Rep 2012*
-
IRef Ophid Interaction:
LEF1
—
CTNNB1
(aggregation, confirmational text mining)
Behrens et al., Nature 1996
-
IRef Ophid Interaction:
LEF1
—
CTNNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Orsulic et al., J Cell Sci 1999
:
E-cadherin binding prevents
beta-catenin nuclear localization and
beta-catenin/LEF-1 mediated
transactivation
Shtutman et al., Proc Natl Acad Sci U S A 1999
(Colonic Neoplasms) :
Elevated
beta-catenin levels in colorectal cancer caused by mutations in beta-catenin or by the adenomatous polyposis coli molecule, which regulates beta-catenin degradation,
result in the binding of beta-catenin to
LEF-1 and increased transcriptional activation of mostly unknown target genes
DasGupta et al., Development 1999
:
In mice, TOPGAL expression was directly stimulated by a stabilized form of
beta -catenin , but was also
dependent upon
LEF1/TCF3 in skin
Ben-Ze'ev et al., Ann N Y Acad Sci 1999
(Cell Transformation, Neoplastic) :
Overexpression of wt plakoglobin or mutant
beta-catenin lacking the transactivation domain
induced nuclear accumulation of the endogenous beta-catenin and
LEF-1-responsive transactivation
von Kries et al., Nat Struct Biol 2000
:
Interactions between beta-catenin and
LEF-1/TCF , APC and conductin/axin are
essential for wnt controlled stabilization of
beta-catenin and transcriptional activation
Kim et al., Cell Biol Int 2001
:
Here, we investigated the
effects of beta-catenin and
LEF-1 on nuclear import of
beta-catenin using different combinations of exogenous and endogenous molecules over longer lengths of time than previously studied
Filali et al., J Biol Chem 2002
:
Wnt-3A/beta-catenin signaling
induces transcription from the
LEF-1 promoter
Kim et al., Cell Biol Int 2002
:
beta-catenin has been shown to
activate LEF-1 transcription during EMT induced in vitro by c-Fos ... In normal epithelial cell lines, such as HCE and MDCK cells, that contain functional APC, nuclear
beta-catenin induced by exogenous
LEF-1 is rapidly exported and EMT is not induced ... Our experiments demonstrated, however, that overexpressed
LEF-1 upregulates nuclear
beta-catenin and promotes dramatic EMT in DLD-1 epithelial tumors that retain nuclear beta-catenin ... Thus, our results demonstrate that
LEF-1 can
induce EMT directly when its transcription activity is activated by stable nuclear
beta-catenin
Saito et al., Pigment Cell Res 2003
:
The bHLH-LZ region of MITF-M is responsible for the physical interaction with
LEF-1 , and
beta-catenin is
required for the collaboration between LEF-1 and MITF-M
Li et al., J Biol Chem 2004
:
Furthermore, GRIP1 and
beta-catenin can synergistically
enhance the activity of both AR and
Lef1 , and both coactivators are recruited specifically to AR-driven and Lef1-driven promoters
Toncheva et al., Tumour Biol 2004
(Colonic Neoplasms...) :
Elevated
beta-catenin levels in colorectal cancer
result in the binding of beta-catenin to
LEF-1 and increased transcriptional activation of the CCND1 gene
Sasaki et al., Dev Biol 2005
:
LEF1 is a cell-type-specific transcription factor and
mediates Wnt signaling pathway by association with its co-activator
beta-catenin
Vadlamudi et al., J Cell Sci 2005
:
Furthermore,
beta-catenin in combination with PITX2 synergistically
activates the
LEF-1 promoter and this activation is independent of the Wnt-responsive element
Asally et al., Exp Cell Res 2005
:
These findings indicate that
beta-catenin alone can
mediate the nuclear import of
lef-1 through the direct binding
Ki et al., Cell Biol Int 2006
(Neoplasms) :
Colon carcinoma cells containing an adenomatous polyposis coli mutation retain significant amounts of
LEF-1 induced nuclear
beta-catenin considerably after the time-point when beta-catenin disappears from the nuclei of LEF-1 transfected normal epithelial cells
Takeda et al., Nat Med 2006
(Adenoma...) :
Mutant
LEF1 not only
inhibited expression of
beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors
Xiong et al., Dev Cell 2006
:
Mechanistically, Tob1a
inhibits beta-catenin transcriptional activity by physically associating with beta-catenin and preventing the formation of
beta-catenin/LEF1 complexes
Amen et al., Mol Cell Biol 2007
:
PITX2 and
beta-catenin interactions
regulate Lef-1 isoform expression
Feigin et al., Cell Signal 2008
(Osteopetrosis) :
OSTM1 regulates
beta-catenin/Lef1 interaction and is
required for
Wnt/beta-catenin signaling
Varea et al., PloS one 2009
:
The transcriptional activation of
beta-catenin is
dependent on
lymphoid enhancer binding factor-1 ( LEF-1 ) and a truncated-mutant of LEF-1 almost completely blocks estradiol TCF mediated transcription
Novak et al., Proc Natl Acad Sci U S A 1998
(Cell Transformation, Neoplastic...) :
We now show that modest overexpression of ILK in intestinal epithelial cells as well as in mammary epithelial cells results in an invasive phenotype concomitant with a down-regulation of E-cadherin expression, translocation of
beta-catenin to the nucleus, formation of a complex between beta-catenin and the high mobility group transcription factor, LEF-1, and transcriptional
activation by this
LEF-1/beta-catenin complex
Simcha et al., J Cell Biol 1998
:
Overexpression of wild-type plakoglobin or mutant
beta-catenin lacking the transactivation domain
induced accumulation of the endogenous beta-catenin in the nucleus and
LEF-1-responsive transactivation