Gene interactions and pathways from curated databases and text-mining

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ESAT — IL10

Text-mined interactions from Literome

Menon et al., J Interferon Cytokine Res 2002 : The presence of ESAT-6 as a fusion partner with P71 during immunization, however, resulted in an enhanced P71-specific IFN-gamma response, decreased release of IL-10 , and significantly greater ( p < 0.05 ) IgG2a antibody levels in comparison to immunizing with P71 alone
Al-Attiyah et al., FEMS Immunol Med Microbiol 2006 (Tuberculosis, Pulmonary) : The secretion of IFN-gamma, but not IL-10 , in the presence of Ag85B, ESAT6 and MPT64 supports their potential as subunit vaccine candidates against TB
Peng et al., J Biol Chem 2011 (Latent Tuberculosis) : SB203580 did not reverse ESAT-6 mediated inhibition of IL-17 and IL-10 production, suggesting a specific effect of SB203580 on IFN-? production
Pinheiro et al., Clin Exp Immunol 2013 (Tuberculosis, Multidrug-Resistant...) : In addition, increased IL-10 secretion was observed in cultured MDR-TB cells following ESAT-6 stimulation, but not in NR-TB or NTM patients