Guillemot et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Fujino et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Furthermore, this activation of PI3K/ERK signaling by the EP ( 4 ) receptors induces the functional expression of early growth response factor-1 (EGR-1) Shin et al., EMBO J 2006
:
Inhibition of PI3K signaling restored the downregulation of SRF and Egr-1 expression caused by oncogenic Ras