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CASP3 — GZMB
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
GZMB
—
CASP3
(direct interaction, enzymatic study)
Zhao et al., Cell Death Differ 2007*
-
IRef Hprd Interaction:
GZMB
—
CASP3
(in vivo)
Kamada et al., Oncogene 1997*, Atkinson et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
GZMB
—
CASP3
(in vitro)
Kamada et al., Oncogene 1997*, Atkinson et al., J Biol Chem 1998*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Goping et al., J Cell Sci 2006*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Quan et al., Proc Natl Acad Sci U S A 1996*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Wang et al., J Exp Med 2001*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Cullen et al., J Biol Chem 2009*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Adrain et al., J Biol Chem 2005*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Casciola-Rosen et al., J Biol Chem 2007*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Cullen et al., J Cell Biol 2007*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Fernandes-Alnemri et al., Proc Natl Acad Sci U S A 1996*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Classen et al., Haematologica 2003*
-
IRef Innatedb Interaction:
GZMB
—
CASP3
(unknown, -)
Adrain et al., J Biol Chem 2006*
-
IRef Ophid Interaction:
GZMB
—
CASP3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Tepper et al., Blood 1999
(Burkitt Lymphoma) :
The apoptotic pathway distal to the DISC is intact because ceramide analogs, staurosporine, and
granzyme B activate
caspase-3 and induce apoptosis
Pathan et al., J Biol Chem 2001
(Neoplasms) :
TUCAN interferes with binding of Apaf1 to procaspase-9 and suppresses
caspase activation
induced by the Apaf1 activator, cytochrome c. Overexpression of TUCAN in cells by stable or transient transfection inhibits apoptosis and caspase activation induced by Apaf1/caspase-9 dependent stimuli, including Bax, VP16, and staurosporine, but not by Apaf1/caspase-9 independent stimuli, Fas and
granzyme B
Jerome et al., J Immunol 2001
:
In contrast,
caspase 3
activation in mitochondria-free cell lysates by
granzyme ( gr ) B was inhibited equivalently by Us5 deletion and rescue viruses, suggesting that gJ is not required for HSV to inhibition this process
Goping et al., Immunity 2003
:
Thus
granzyme B mediates direct cleavage of
caspase 3 and also activates mitochondrial disruption, resulting in the release of proapoptotic proteins that suppress caspase inhibition
Fellows et al., Blood 2007
:
Although GzmH is most closely related to the
caspase activating
granzyme B (GzmB) , neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme
Quan et al., Proc Natl Acad Sci U S A 1996
:
Proteolytic
activation of the cell death protease
Yama/CPP32 by
granzyme B
Chinnaiyan et al., Curr Biol 1996
:
Previous studies have shown that
granzyme B proteolytically
activates the cell death effector
Yama/CPP32/apopain ( referred to here as Yama )
Zapata et al., J Biol Chem 1998
:
Since the
granzyme B is a direct
activator of
caspase-3 and its expression is induced following T-cell activation, we tested the effects of anti-GraB, an engineered serpin that specifically inhibits GraB