Irie et al., FEBS Lett 1999
:
The results revealed that TRAF6 mediated NF-kappaB activation was suppressed by p75 ( NTR ) and that the p75 ( NTR ) -mediated NF-kappaB suppression was reduced by FAP-1 expression
Wieckowski et al., J Cell Biochem 2007
(Carcinoma, Squamous Cell...) :
FAP-1 mediated activation of NF-kappaB induces resistance of head and neck cancer to Fas induced apoptosis ... Treatment with the phosphatase inhibitor, orthovanadate, or silencing of FAP-1 with siRNA abolished their resistance to apoptosis, suggesting that FAP-1 phosphatase activity could be responsible for NF-kappaB activation and resistance of SCCHN cells to Fas mediated apoptosis
Maekawa et al., Biochem J 1999
:
PTP-BAS may thus play a regulatory role in activation of NF-kappaB under high oxidative stress