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CDH1 — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
RAC1/GTP/IQGAP1 complex (RAC1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
RAC1/GTP complex (RAC1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, activates)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database a6b1 and a6b4 Integrin signaling:
Rac1b/GTP complex (RAC1)
→
E-cadherin (CDH1)
(cell adhesion, collaborate)
Hintermann et al., J Biol Chem 2005*, Chartier et al., J Cell Sci 2006
Evidence: expresssion pattern, mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RAC1-CDC42/GTP/IQGAP1 complex (RAC1_CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
Text-mined interactions from Literome
Kovacs et al., J Biol Chem 2002
:
In this study, we used a functional cadherin ligand ( hE/Fc ) to directly test whether
E-cadherin ligation
regulates phosphatidylinositol 3-kinase ( PI 3-kinase ) and
Rac signaling ... We report that homophilic
cadherin ligation recruits Rac to nascent adhesive contacts and specifically
stimulates Rac signaling
Goodwin et al., J Biol Chem 2003
:
Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase : direct evidence of a role for
cadherin activated
Rac signaling in adhesion and contact formation ... These data provide direct evidence for a role of
cadherin activated
Rac signaling in contact formation and adhesive stabilization
Honda et al., Genes Cells 2003
:
Cdc42 or
Rac was not
essential for the association of nectin-1 and
E-cadherin to form AJs
Noritake et al., Mol Biol Cell 2004
:
The small guanosine triphosphatase
Rac1 is activated by E-cadherin mediated cell-cell adhesion and is
required for the accumulation of actin filaments,
E-cadherin , and beta-catenin at sites of cell-cell contact ... Together, these results indicate that
Rac1 enhances the accumulation of actin filaments,
E-cadherin , and beta-catenin by acting on IQGAP1 and suggest that there exists a positive feedback loop comprised of "E-cadherin mediated cell-cell adhesion -- > Rac1 activation -- > actin-meshwork formation by IQGAP1 -- > increasing E-cadherin mediated cell-cell adhesion. ''
Hoshino et al., Mol Biol Cell 2004
:
A novel role of nectins in inhibition of the
E-cadherin induced activation of
Rac and formation of cell-cell adherens junctions ... Moreover, we found here that the nectins, which did not trans-interact with other nectins ( non-trans interacting nectins ), inhibited the
E-cadherin induced activation of
Rac and reduced the velocity of the formation of the E-cadherin based cell-cell AJs ... These results indicate a novel role of nectins in regulation of the
E-cadherin induced activation of
Rac and formation of cell-cell AJs
Fukuyama et al., Oncogene 2006
:
Activation of
Rac by
cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway ... However, it has not fully been understood how
cadherin induces the activation of
Rac
Matsuda et al., J Mol Cell Cardiol 2006
:
RhoA and
Rac1 activation was
inhibited by the transfection of dominant negative
N-cadherin , indicating that RhoA and Rac1 were activated by N-cadherin in the oriented cardiac myocytes
Liu et al., J Cell Biol 2006
:
Rac1 activity, which was
induced by
E-cadherin engagement specifically at intermediate seeding densities, was required for the cadherin stimulated proliferation, and the control of Rac1 activation by E-cadherin was mediated by p120-catenin
Kraemer et al., Am J Physiol Cell Physiol 2007
:
We found that homophilic engagement of
E-cadherin simultaneously
activates both
Rac1 and Cdc42 ... To pursue upstream elements of the Rac1 signaling pathway, we focused on the potential contribution of Tiam1 to
cadherin activated
Rac signaling
Esufali et al., Cancer Res 2007
(Colorectal Neoplasms) :
Furthermore, we show that
Rac1b negatively
regulates E-cadherin expression and results in decreased adhesion of colorectal cancer cells
Perez et al., J Biol Chem 2008
:
We propose that initial E-cadherin accumulation requires active membrane dynamics and involves diffusion mediated trapping at contact sites ; to propagate further contacts, phosphatidylinositol 3-kinase and
Rac1 are transiently
activated by
E-cadherin engagement and initiate a new round of membrane dynamics, but they are subsequently suppressed at that site to allow maintenance of weak E-cadherin mediated adhesion
Sakisaka et al., Methods Mol Biol 2008
:
The endocytosis of trans interacting E-cadherin was inhibited by
Rac and Cdc42 small G proteins, which were
activated by trans interacting
E-cadherin
Kitt et al., PloS one 2011
:
Inhibition of
E-cadherin engagement with DECMA-1 Fab fragments or competitive binding of soluble E-cadherin, or nectin2alpha extracellular domain completely
inhibited Rac1 activity
Hu et al., Tumour Biol 2012
(Liver Neoplasms...) :
miR-143 expression significantly decreased mRNA and protein levels of GEF1, GEF2, and K-RAS genes ; lowered the constitutive activities of RhoA,
Rac1 , and Cdc42 GTPases ; decreased the protein levels of MMP-2 and MMP-9 ; but significantly
increased the protein level of
E-cadherin