Gene interactions and pathways from curated databases and text-mining

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RAC1 — TNFSF11

Text-mined interactions from Literome

Lee et al., Mol Cell Biochem 2006 : We show here that TRANCE selectively activates Rac1 , but not Rac2 in osteoclast precursors ... Expression of a dominant interfering mutant of TNF receptor associated factor (TRAF)6 blocks TRANCE mediated Rac1 activation, indicating that Rac1 lies downstream of TRAF6
Kim et al., J Biol Chem 2010 (Calcium Signaling) : The pathway includes RANKL mediated stimulation of Rac1 to generate ROS, which stimulate phospholipase Cgamma1 to evoke [ Ca ( 2+ ) ] ( i ) oscillations by stimulating Ca ( 2+ ) release from the inositol 1,4,5-trisphosphate pool and STIM1 regulated Ca ( 2+ ) influx