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RAC1 — TNFSF11
Text-mined interactions from Literome
Lee et al., Mol Cell Biochem 2006
:
We show here that
TRANCE selectively
activates Rac1 , but not Rac2 in osteoclast precursors ... Expression of a dominant interfering mutant of TNF receptor associated factor (TRAF)6 blocks
TRANCE mediated
Rac1 activation, indicating that Rac1 lies downstream of TRAF6
Kim et al., J Biol Chem 2010
(Calcium Signaling) :
The pathway includes
RANKL mediated stimulation of
Rac1 to generate ROS, which stimulate phospholipase Cgamma1 to evoke [ Ca ( 2+ ) ] ( i ) oscillations by stimulating Ca ( 2+ ) release from the inositol 1,4,5-trisphosphate pool and STIM1 regulated Ca ( 2+ ) influx