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SDC1 — TNF

Text-mined interactions from Literome

Sebestyén et al., Cytokine 2000 : In the present work the regulatory effect of IL-1beta, IL-6, TNF-alpha , IFN-gamma and TGF-beta1 on syndecan-1 and syndecan-2 expression of hepatocytes, hepatoma cell lines, liver and skin fibroblasts has been studied
Day et al., Cytokine 2003 : Stimulation of HT29 cells with TNF-alpha and IL-1beta resulted in reversible down-regulation of syndecan-1 at both protein and mRNA levels but little effect was observed with IL-6
Zhang et al., Inflamm Bowel Dis 2013 (Crohn Disease...) : Recombinant HPA incubation increased soluble SDC1 in culture supernatants ( P = 2 x 10 ( -4 ) ), and low-dose TNF-a effectively enhanced HPA 's activity ( P = 3 x 10 ( -6 ) )
Kainulainen et al., J Biol Chem 1996 : None of these factors significantly altered syndecan-1 mRNA expression in cultured keratinocytes, but when given to endothelial cells, tumor necrosis factor-alpha (TNF-alpha) specifically and dose-dependently suppressed syndecan-1 expression at both mRNA and protein levels ... The suppressive effect of TNF-alpha on endothelial syndecan-1 expression was reproducible in in vivo experiments in which TNF-alpha coated beads were administered directly to healing skin wounds of mice ... In this tissue TNF-alpha suppressed syndecan-1 mRNA expression by approximately 80 %