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RAC2 — SRC

Pathways - manually collected, often from reviews:

• KEGG Adherens junction: SRC → RAC1/RAC2/RAC3 (protein-protein, indirect effect)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: SRC — RAC2 (interaction, mapped from kegg_pathways)
• STRING interaction: SRC — RAC2 (interaction, mapped from kegg_pathways)
• STRING interaction: RAC2 — SRC (interaction, mapped from kegg_pathways)
• STRING interaction: RAC2 — SRC (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Marignani et al., J Cell Biol 2001 : Vav2 nucleotide exchange is Src dependent in vivo, since the coexpression of Vav2 and dominant negative Src , or treatment with the Src inhibitor PP2, blocks both Vav2 dependent Rac activation and lamellipodia formation
Hsia et al., J Cell Biol 2003 (Neoplasm Invasiveness...) : Cell invasion was linked to transient FAK accumulation at lamellipodia, formation of a FAK-Src-p130Cas-Dock180 signaling complex, elevated Rac and c-Jun NH2-terminal kinase activation , and increased matrix metalloproteinase expression and activity
Servitja et al., J Biol Chem 2003 (Cell Transformation, Neoplastic) : Evidence of a role for Tiam1 and Vav2 in Rac activation by Src
Shimizu et al., J Biochem 2003 : Nectin furthermore induces activation of Cdc42 and Rac small G proteins through c-Src , which eventually regulates formation of the cadherin based adherens junctions through reorganization of the actin cytoskeleton, gene expression through activation of a mitogen activated protein kinase cascade, and cell polarization through cell polarity proteins
Sato et al., Cancer Sci 2005 : The activation of Cdc42 and Rac by the trans-interaction of nectin and nectin is mediated by c-Src , another small G protein, Rap1, a Cdc42-GEF, FRG, and a Rac-GEF, Vav2
Murata et al., J Neurosci 2006 : CD47 promotes neuronal development through Src- and FRG/Vav2 mediated activation of Rac and Cdc42 ... These results indicate that CD47 promotes development of dendrites and axons in hippocampal neurons in a manner dependent, at least in part, on activation of Cdc42 and Rac mediated by Src as well as by FRG and Vav2
Dise et al., Am J Physiol Gastrointest Liver Physiol 2008 : Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration
Chaudhry et al., Cell Host Microbe 2007 (HIV Infections) : At the cell surface, Src promotes Rac activation via TIAM, a guanine nucleotide exchange factor for Rac
Sai et al., J Biol Chem 2008 : We hypothesized that Src regulated ELMO-Dock2-Rac2 activation mediates chemotaxis in the absence of PI3K activity
Putnam et al., Cell communication and signaling : CCS 2009 : Src had no effect on Rac activity
Lee et al., Carcinogenesis 2011 (Anoxia) : Using biochemical and genetic inhibition, we demonstrated that Src requires reduced nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase/Rac complex for stabilization of HIF-1a
Arpaia et al., Oncogene 2012 (Neoplasm Metastasis...) : Our data indicate that interaction between Cav1 and Rho-GTPases ( most likely RhoC but not RhoA ) promotes metastasis by stimulating a5-integrin expression and regulating the Src dependent activation of p130 ( Cas ) /Rac1 , FAK/Pyk2 and Ras/Erk1/2 signaling cascades
Kant et al., Genes Dev 2011 (Inflammation) : This signaling pathway requires Src dependent activation of the guanosine nucleotide exchange factor Vav, activation of Rac/Cdc42 , and the engagement of the Rac/Cdc42 interaction site ( CRIB motif ) on mixed-lineage protein kinases ( MLKs )