Gerbod-Giannone et al., Proc Natl Acad Sci U S A 2006
:
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells
Chen et al., Am J Physiol Cell Physiol 2007
:
In contrast, NF-kappaB inhibition by pyrrolidine dithiocarbamate and MG132 prevented the suppression of ABCA1 by IL-1beta ... Thus our data provide strong evidence that ROS and NF-kappaB , but not LXR, mediate the IL-1beta induced downregulation of ABCA1 via a novel transcriptional mechanism, which might play an important role of proinflammation in the alteration of lipid metabolism
Zuo et al., Arterioscler Thromb Vasc Biol 2009
(Atherosclerosis...) :
Our findings show that mild renal dysfunction perturbs macrophage lipid homeostasis by inhibiting cholesterol efflux, mediated by decreased ABCA1 transporter and activation of NF-kappaB , and that ARB can restore cholesterol efflux